PKD1 (Phospho Tyr463) Rabbit pAb
-YP0721
主要信息
Target
PKD1 Phospho Tyr463
Host Species
Rabbit
Reactivity
Human, Mouse, Rat
Applications
WB, IHC, IF, ELISA
MW
130kD (Observed)
Conjugate/Modification
Phospho
货号: YP0721
规格
价格
货期
数量
200μL
￥4,680.00
现货
0
100μL
￥2,800.00
现货
0
50μL
￥1,500.00
现货
0
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已收藏
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详细信息
推荐稀释比
WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:40000; IF 1:50-200
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
特异性
Phospho-PKD1 (Y463) Polyclonal Antibody detects endogenous levels of PKD1 protein only when phosphorylated at Y463.The name of modified sites may be influenced by many factors, such as species (the modified site was not originally found in human samples) and the change of protein sequence (the previous protein sequence is incomplete, and the protein sequence may be prolonged with the development of protein sequencing technology). When naming, we will use the "numbers" in historical reference to keep the sites consistent with the reports. The antibody binds to the following modification sequence (lowercase letters are modification sites):RYyKE
纯化工艺
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存
-15°C to -25°C/1 year (Do not lower than -25°C)
浓度
1 mg/ml
实测条带
130kD
修饰
Phospho
克隆性
Polyclonal
同种型
IgG
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ELISA Kits
Total PKD1/PKC μ Cell-Based Colorimetric ELISA Kit
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ELISA Kits
PKD1/PKC μ (Phospho Tyr463) Cell-Based Colorimetric ELISA Kit
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ELISA Kits
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抗原&靶点信息
免疫原:
The antiserum was produced against synthesized peptide derived from human PKD1/PKC mu around the phosphorylation site of Tyr463. AA range:429-478
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特异性:
Phospho-PKD1 (Y463) Polyclonal Antibody detects endogenous levels of PKD1 protein only when phosphorylated at Y463.The name of modified sites may be influenced by many factors, such as species (the modified site was not originally found in human samples) and the change of protein sequence (the previous protein sequence is incomplete, and the protein sequence may be prolonged with the development of protein sequencing technology). When naming, we will use the "numbers" in historical reference to keep the sites consistent with the reports. The antibody binds to the following modification sequence (lowercase letters are modification sites):RYyKE
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基因名称:
PRKD1
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蛋白名称:
Serine/threonine-protein kinase D1
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别名:
PRKD1 ;
PKD ;
PKD1 ;
PRKCM ;
Serine/threonine-protein kinase D1 ;
Protein kinase C mu type ;
Protein kinase D ;
nPKC-D1 ;
nPKC-mu
PKD ;
PKD1 ;
PRKCM ;
Serine/threonine-protein kinase D1 ;
Protein kinase C mu type ;
Protein kinase D ;
nPKC-D1 ;
nPKC-mu
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背景:
PRKD1 is a serine/threonine kinase that regulates a variety of cellular functions , including membrane receptor signaling , transport at the Golgi , protection from oxidative stress at the mitochondria , gene transcription , and regulation of cell shape , motility , and adhesion (summary by Eiseler et al. , 2009 [PubMed 19329994]) .[supplied by OMIM , Nov 2010] ,
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功能:
Catalytic activity:ATP + a protein = ADP + a phosphoprotein. ,enzyme regulation:Activated by diacylglycerol and phorbol esters. ,Function:Calcium-independent , phospholipid-dependent , serine- and threonine-specific kinase involved in resistance to oxidative stress. ,PTM:Phosphorylation of Ser-738 and/or Ser-742 in activated PKD is mediated by transphosphorylation (By similarity) . Phosphorylation of Tyr-463 mediated by the Src/Abl pathway in response to oxidative stress activates the kinase. ,similarity:Belongs to the protein kinase superfamily. ,similarity:Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PKD subfamily. ,similarity:Contains 1 PH domain. ,similarity:Contains 1 protein kinase domain. ,similarity:Contains 2 phorbol-ester/DAG-type zinc fingers. ,subunit:Interacts (via N-terminus) with ADAP1/CENTA1. Interacts with Src. ,
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细胞定位:
Cytoplasm . Cell membrane . Golgi apparatus , trans-Golgi network . Translocation to the cell membrane is required for kinase activation.
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组织表达:
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研究领域:
>>Rap1 signaling pathway ;
>>Aldosterone synthesis and secretion ;
>>Chemical carcinogenesis - reactive oxygen species
>>Aldosterone synthesis and secretion ;
>>Chemical carcinogenesis - reactive oxygen species
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信号通路
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货号: YP0721
规格
价格
货期
数量
200μL
￥4,680.00
现货
0
100μL
￥2,800.00
现货
0
50μL
￥1,500.00
现货
0
加入购物车
已收藏
收藏
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