AR-β2 (Phospho Ser355+Ser356) Rabbit pAb
-YP0712
主要信息
Target
Adrenergic Receptor β2 Phospho Ser355+Ser356
Host Species
Rabbit
Reactivity
Human, Mouse, Rat, Monkey
Applications
WB, IHC, IF, ELISA
MW
47kD (Observed)
Conjugate/Modification
Phospho
货号: YP0712
规格
价格
货期
数量
200μL
￥4,680.00
现货
0
100μL
￥2,800.00
现货
0
50μL
￥1,500.00
现货
0
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详细信息
推荐稀释比
WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:10000; IF 1:50-200
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
特异性
This antibody detects endogenous levels of AR-β2 when dually phosphorylated at ser355 and ser356.The name of modified sites may be influenced by many factors, such as species (the modified site was not originally found in human samples) and the change of protein sequence (the previous protein sequence is incomplete, and the protein sequence may be prolonged with the development of protein sequencing technology). When naming, we will use the "numbers" in historical reference to keep the sites consistent with the reports. The antibody binds to the following modification sequence (lowercase letters are modification sites):YssNG
纯化工艺
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存
-15°C to -25°C/1 year (Do not lower than -25°C)
浓度
1 mg/ml
实测条带
47kD
修饰
Phospho
克隆性
Polyclonal
同种型
IgG
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抗原&靶点信息
免疫原:
The antiserum was produced against synthesized peptide derived from human Adrenergic Receptor B2 around the phosphorylation site of Ser355 and Ser356. AA range:331-380
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特异性:
This antibody detects endogenous levels of AR-β2 when dually phosphorylated at ser355 and ser356.The name of modified sites may be influenced by many factors, such as species (the modified site was not originally found in human samples) and the change of protein sequence (the previous protein sequence is incomplete, and the protein sequence may be prolonged with the development of protein sequencing technology). When naming, we will use the "numbers" in historical reference to keep the sites consistent with the reports. The antibody binds to the following modification sequence (lowercase letters are modification sites):YssNG
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基因名称:
ADRB2
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蛋白名称:
Beta-2 adrenergic receptor
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别名:
ADRB2 ;
ADRB2R ;
B2AR ;
Beta-2 adrenergic receptor ;
Beta-2 adrenoreceptor ;
Beta-2 adrenoceptor
ADRB2R ;
B2AR ;
Beta-2 adrenergic receptor ;
Beta-2 adrenoreceptor ;
Beta-2 adrenoceptor
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背景:
This gene encodes beta-2-adrenergic receptor which is a member of the G protein-coupled receptor superfamily. This receptor is directly associated with one of its ultimate effectors , the class C L-type calcium channel Ca (V) 1.2. This receptor-channel complex also contains a G protein , an adenylyl cyclase , cAMP-dependent kinase , and the counterbalancing phosphatase , PP2A. The assembly of the signaling complex provides a mechanism that ensures specific and rapid signaling by this G protein-coupled receptor. This gene is intronless. Different polymorphic forms , point mutations , and/or downregulation of this gene are associated with nocturnal asthma , obesity and type 2 diabetes. [provided by RefSeq , Jul 2008] ,
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功能:
Disease:Polymorphic forms of ADRB2 could impart some form of nocturnal asthma. ,Function:Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. The beta-2-adrenergic receptor binds epinephrine with an approximately 30-fold greater affinity than it does norepinephrine. ,PTM:Palmitoylated; may reduce accessibility of Ser-345 and Ser-346 by anchoring Cys-341 to the plasma membrane. Agonist stimulation promotes depalmitoylation and further allows Ser-345 and Ser-346 phosphorylation. ,PTM:Phosphorylated by PKA and BARK upon agonist stimulation , which mediates homologous desensitization of the receptor. PKA-mediated phosphorylation seems to facilitate phosphorylation by BARK. Phosphorylated upon DNA damage , probably by ATM or ATR. ,PTM:Phosphorylation of Tyr-141 is induced by insulin and leads to supersensitization of the receptor. ,similarity:Belongs to the G-protein coupled receptor 1 family. ,subunit:Binds SLC9A3R1 and GPRASP1. ,
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细胞定位:
Cell membrane ; Multi-pass membrane protein . Early endosome . Golgi apparatus . Colocalizes with VHL at the cell membrane (PubMed:19584355) . Activated receptors are internalized into endosomes prior to their degradation in lysosomes (PubMed:20559325) . Activated receptors are also detected within the Golgi apparatus (PubMed:27481942) . .
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研究领域:
>>Calcium signaling pathway ;
>>cGMP-PKG signaling pathway ;
>>cAMP signaling pathway ;
>>Neuroactive ligand-receptor interaction ;
>>Adrenergic signaling in cardiomyocytes ;
>>Regulation of lipolysis in adipocytes ;
>>Renin secretion ;
>>Salivary secretion ;
>>Chemical carcinogenesis - receptor activation
>>cGMP-PKG signaling pathway ;
>>cAMP signaling pathway ;
>>Neuroactive ligand-receptor interaction ;
>>Adrenergic signaling in cardiomyocytes ;
>>Regulation of lipolysis in adipocytes ;
>>Renin secretion ;
>>Salivary secretion ;
>>Chemical carcinogenesis - receptor activation
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信号通路
Organismal Systems >> Circulatory system >> Adrenergic signaling in cardiomyocytes
Environmental Information Processing >> Signal transduction >> Calcium signaling pathway
Environmental Information Processing >> Signal transduction >> cAMP signaling pathway
Environmental Information Processing >> Signal transduction >> cGMP-PKG signaling pathway
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货号: YP0712
规格
价格
货期
数量
200μL
￥4,680.00
现货
0
100μL
￥2,800.00
现货
0
50μL
￥1,500.00
现货
0
加入购物车
已收藏
收藏
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