The antiserum was produced against synthesized peptide derived from human CrkL around the phosphorylation site of Tyr207. AA range:173-222

Phospho-Crk-L (Y207) Polyclonal Antibody detects endogenous levels of Crk-L protein only when phosphorylated at Y207.The name of modified sites may be influenced by many factors, such as species (the modified site was not originally found in human samples) and the change of protein sequence (the previous protein sequence is incomplete, and the protein sequence may be prolonged with the development of protein sequencing technology). When naming, we will use the "numbers" in historical reference to keep the sites consistent with the reports. The antibody binds to the following modification sequence (lowercase letters are modification sites):HAyAQ

CRKL

Crk-like protein

CRKL ;
Crk-like protein

This gene encodes a protein kinase containing SH2 and SH3 (src homology) domains which has been shown to activate the RAS and JUN kinase signaling pathways and transform fibroblasts in a RAS-dependent fashion. It is a substrate of the BCR-ABL tyrosine kinase, plays a role in fibroblast transformation by BCR-ABL, and may be oncogenic.[provided by RefSeq, Jan 2009],

Function:May mediate the transduction of intracellular signals.,similarity:Contains 1 SH2 domain.,similarity:Contains 2 SH3 domains.,subunit:Interacts with INPP5D/SHIP1. Interacts with DOCK2 and EPOR. Interacts with phosphorylated CBLB and IRS4.,

endosome,cytosol,cell-cell adherens junction,extracellular exosome,

>>MAPK signaling pathway ;
>>ErbB signaling pathway ;
>>Rap1 signaling pathway ;
>>Chemokine signaling pathway ;
>>Focal adhesion ;
>>Fc gamma R-mediated phagocytosis ;
>>Neurotrophin signaling pathway ;
>>Regulation of actin cytoskeleton ;
>>Insulin signaling pathway ;
>>Growth hormone synthesis, secretion and action ;
>>Bacterial invasion of epithelial cells ;
>>Shigellosis ;
>>Yersinia infection ;
>>Human cytomegalovirus infection ;
>>Human immunodeficiency virus 1 infection ;
>>Pathways in cancer ;
>>MicroRNAs in cancer ;
>>Renal cell carcinoma ;
>>Chronic myeloid leukemia