ATP-citrate Lyase (Phospho Ser455) Rabbit pAb
-YP0686
主要信息
Target
ATP-citrate synthase Phospho Ser455
Host Species
Rabbit
Reactivity
Human, Mouse, Rat, Monkey
Applications
WB, IHC, IF, ELISA
MW
125kD (Observed)
Conjugate/Modification
Phospho
货号: YP0686
规格
价格
货期
数量
200μL
￥4,680.00
现货
0
100μL
￥2,800.00
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0
50μL
￥1,500.00
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0
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详细信息
推荐稀释比
WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:10000; IF 1:50-200
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
特异性
Phospho-ATP-citrate Lyase (S455) Polyclonal Antibody detects endogenous levels of ATP-citrate Lyase protein only when phosphorylated at S455.The name of modified sites may be influenced by many factors, such as species (the modified site was not originally found in human samples) and the change of protein sequence (the previous protein sequence is incomplete, and the protein sequence may be prolonged with the development of protein sequencing technology). When naming, we will use the "numbers" in historical reference to keep the sites consistent with the reports. The antibody binds to the following modification sequence (lowercase letters are modification sites):TAsFS
纯化工艺
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存
-15°C to -25°C/1 year (Do not lower than -25°C)
浓度
1 mg/ml
实测条带
125kD
修饰
Phospho
克隆性
Polyclonal
同种型
IgG
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抗原&靶点信息
免疫原:
The antiserum was produced against synthesized peptide derived from human ATP-Citrate Lyase around the phosphorylation site of Ser454. AA range:420-469
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特异性:
Phospho-ATP-citrate Lyase (S455) Polyclonal Antibody detects endogenous levels of ATP-citrate Lyase protein only when phosphorylated at S455.The name of modified sites may be influenced by many factors, such as species (the modified site was not originally found in human samples) and the change of protein sequence (the previous protein sequence is incomplete, and the protein sequence may be prolonged with the development of protein sequencing technology). When naming, we will use the "numbers" in historical reference to keep the sites consistent with the reports. The antibody binds to the following modification sequence (lowercase letters are modification sites):TAsFS
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基因名称:
ACLY
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蛋白名称:
ATP-citrate synthase
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别名:
ACLY ;
ATP-citrate synthase ;
ATP-citrate ;
pro-S- ;
-lyase ;
ACL ;
Citrate cleavage enzyme
ATP-citrate synthase ;
ATP-citrate ;
pro-S- ;
-lyase ;
ACL ;
Citrate cleavage enzyme
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背景:
ATP citrate lyase (ACLY) Homo sapiens ATP citrate lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. The enzyme is a tetramer (relative molecular weight approximately 440 ,000) of apparently identical subunits. It catalyzes the formation of acetyl-CoA and oxaloacetate from citrate and CoA with a concomitant hydrolysis of ATP to ADP and phosphate. The product , acetyl-CoA , serves several important biosynthetic pathways , including lipogenesis and cholesterogenesis. In nervous tissue , ATP citrate-lyase may be involved in the biosynthesis of acetylcholine. Multiple transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq , Dec 2014] ,
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功能:
Catalytic activity:ADP + phosphate + acetyl-CoA + oxaloacetate = ATP + citrate + CoA. ,Function:ATP citrate-lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. Has a central role in de novo lipid synthesis. In nervous tissue it may be involved in the biosynthesis of acetylcholine. ,similarity:In the C-terminal section; belongs to the succinate/malate CoA ligase alpha subunit family. ,similarity:In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family. ,subunit:Homotetramer. ,
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细胞定位:
Cytoplasm , cytosol .
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研究领域:
>>Citrate cycle (TCA cycle) ;
>>Metabolic pathways
>>Metabolic pathways
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货号: YP0686
规格
价格
货期
数量
200μL
￥4,680.00
现货
0
100μL
￥2,800.00
现货
0
50μL
￥1,500.00
现货
0
加入购物车
已收藏
收藏
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