The antiserum was produced against synthesized peptide derived from human STAT2 around the phosphorylation site of Tyr690. AA range:656-705

Phospho-STAT2 (Y690) Polyclonal Antibody detects endogenous levels of STAT2 protein only when phosphorylated at Y690.The name of modified sites may be influenced by many factors, such as species (the modified site was not originally found in human samples) and the change of protein sequence (the previous protein sequence is incomplete, and the protein sequence may be prolonged with the development of protein sequencing technology). When naming, we will use the "numbers" in historical reference to keep the sites consistent with the reports. The antibody binds to the following modification sequence (lowercase letters are modification sites):RKyLK

STAT2

Signal transducer and activator of transcription 2

STAT2 ;
Signal transducer and activator of transcription 2 ;
p113

The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors , STAT family members are phosphorylated by the receptor associated kinases , and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. In response to interferon (IFN) , this protein forms a complex with STAT1 and IFN regulatory factor family protein p48 (ISGF3G) , in which this protein acts as a transactivator , but lacks the ability to bind DNA directly. Transcription adaptor P300/CBP (EP300/CREBBP) has been shown to interact specifically with this protein , which is thought to be involved in the process of blocking IFN-alpha response by adenovirus. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq , Mar 2010] ,

Function:Signal transducer and activator of transcription that mediates signaling by type I IFNs (IFN-alpha and IFN-beta) . Following type I IFN binding to cell surface receptors , Jak kinases (TYK2 and JAK1) are activated , leading to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize , associate with ISGF3G/IRF-9 to form a complex termed ISGF3 transcription factor , that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes , which drive the cell in an antiviral state. ,PTM:Tyrosine phosphorylated in response to IFN-alpha. ,similarity:Belongs to the transcription factor STAT family. ,similarity:Contains 1 SH2 domain. ,subcellular location:Translocated into the nucleus upon activation by IFN-alpha/beta. ,subunit:Interacts with ISGF3G/IRF-9 in the cytoplasm. Heterodimer with STAT1 upon IFN-alpha/beta induced phosphorylation. Interacts with CRSP2 and CRSP6. Interacts with Simian virus 5 protein V and rabies virus phosphoprotein. ,

Cytoplasm . Nucleus . Translocated into the nucleus upon activation by IFN-alpha/beta. .

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