HSL (Phospho Ser855) Rabbit pAb
-YP0602
主要信息
Target
HSL Phospho Ser855
Host Species
Rabbit
Reactivity
Human, Mouse, Rat
Applications
WB, IHC, IF, ELISA
MW
81kD (Observed)
Conjugate/Modification
Phospho
货号: YP0602
规格
价格
货期
数量
200μL
￥4,680.00
现货
0
100μL
￥2,800.00
现货
0
50μL
￥1,500.00
现货
0
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详细信息
推荐稀释比
WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:20000; IF 1:50-200
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
特异性
Phospho-HSL (S855) Polyclonal Antibody detects endogenous levels of HSL protein only when phosphorylated at S855.The name of modified sites may be influenced by many factors, such as species (the modified site was not originally found in human samples) and the change of protein sequence (the previous protein sequence is incomplete, and the protein sequence may be prolonged with the development of protein sequencing technology). When naming, we will use the "numbers" in historical reference to keep the sites consistent with the reports. The antibody binds to the following modification sequence (lowercase letters are modification sites):SVsEA
纯化工艺
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存
-15°C to -25°C/1 year (Do not lower than -25°C)
浓度
1 mg/ml
实测条带
81kD
修饰
Phospho
克隆性
Polyclonal
同种型
IgG
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抗原&靶点信息
免疫原:
The antiserum was produced against synthesized peptide derived from human HSL around the phosphorylation site of Ser855/554. AA range:520-569
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特异性:
Phospho-HSL (S855) Polyclonal Antibody detects endogenous levels of HSL protein only when phosphorylated at S855.The name of modified sites may be influenced by many factors, such as species (the modified site was not originally found in human samples) and the change of protein sequence (the previous protein sequence is incomplete, and the protein sequence may be prolonged with the development of protein sequencing technology). When naming, we will use the "numbers" in historical reference to keep the sites consistent with the reports. The antibody binds to the following modification sequence (lowercase letters are modification sites):SVsEA
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基因名称:
LIPE
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蛋白名称:
Hormone-sensitive lipase
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别名:
LIPE ;
Hormone-sensitive lipase ;
HSL
Hormone-sensitive lipase ;
HSL
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背景:
The protein encoded by this gene has a long and a short form , generated by use of alternative translational start codons. The long form is expressed in steroidogenic tissues such as testis , where it converts cholesteryl esters to free cholesterol for steroid hormone production. The short form is expressed in adipose tissue , among others , where it hydrolyzes stored triglycerides to free fatty acids. [provided by RefSeq , Jul 2008] ,
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功能:
Catalytic activity:Diacylglycerol + H (2) O = monoacylglycerol + a carboxylate. ,Catalytic activity:Monoacylglycerol + H (2) O = glycerol + a carboxylate. ,Catalytic activity:Triacylglycerol + H (2) O = diacylglycerol + a carboxylate. ,enzyme regulation:Rapidly activated by cAMP-dependent phosphorylation under the influence of catecholamines. Dephosphorylation and inactivation are controlled by insulin. ,Function:In adipose tissue and heart , it primarily hydrolyzes stored triglycerides to free fatty acids , while in steroidogenic tissues , it principally converts cholesteryl esters to free cholesterol for steroid hormone production. ,pathway:Glycerolipid metabolism; triacylglycerol degradation. ,similarity:Belongs to the 'GDXG' lipolytic enzyme family. ,subcellular location:Found in the high-density caveolae. Translocates to the cytoplasm from the caveolae upon insulin stimulation. ,subunit:Interacts with PTRF in the adipocyte cytoplasm. ,
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细胞定位:
Cell membrane . Membrane , caveola . Cytoplasm , cytosol . Lipid droplet . Found in the high-density caveolae. Translocates to the cytoplasm from the caveolae upon insulin stimulation (PubMed:17026959) . Phosphorylation by AMPK reduces its translocation towards the lipid droplets (By similarity) . .
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组织表达:
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研究领域:
>>cAMP signaling pathway ;
>>AMPK signaling pathway ;
>>Apelin signaling pathway ;
>>Thermogenesis ;
>>Insulin signaling pathway ;
>>Regulation of lipolysis in adipocytes ;
>>Aldosterone synthesis and secretion
>>AMPK signaling pathway ;
>>Apelin signaling pathway ;
>>Thermogenesis ;
>>Insulin signaling pathway ;
>>Regulation of lipolysis in adipocytes ;
>>Aldosterone synthesis and secretion
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信号通路
Organismal Systems >> Endocrine system >> Insulin signaling pathway
Organismal Systems >> Endocrine system >> Aldosterone synthesis and secretion
Environmental Information Processing >> Signal transduction >> Apelin signaling pathway
Environmental Information Processing >> Signal transduction >> cAMP signaling pathway
Environmental Information Processing >> Signal transduction >> AMPK signaling pathway
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货号: YP0602
规格
价格
货期
数量
200μL
￥4,680.00
现货
0
100μL
￥2,800.00
现货
0
50μL
￥1,500.00
现货
0
加入购物车
已收藏
收藏
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