ERK 3 (Phospho Ser189) Rabbit pAb
-YP0738
主要信息
Target
ERK 3 Phospho Ser189
Host Species
Rabbit
Reactivity
Human, Mouse, Rat
Applications
WB, IHC, IF, ELISA
MW
90kD (Observed)
Conjugate/Modification
Phospho
货号: YP0738
规格
价格
货期
数量
200μL
￥4,680.00
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0
100μL
￥2,800.00
现货
0
50μL
￥1,500.00
现货
0
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详细信息
推荐稀释比
WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:5000; IF 1:50-200
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
特异性
Phospho-ERK 3 (S189) Polyclonal Antibody detects endogenous levels of ERK 3 protein only when phosphorylated at S189.The name of modified sites may be influenced by many factors, such as species (the modified site was not originally found in human samples) and the change of protein sequence (the previous protein sequence is incomplete, and the protein sequence may be prolonged with the development of protein sequencing technology). When naming, we will use the "numbers" in historical reference to keep the sites consistent with the reports. The antibody binds to the following modification sequence (lowercase letters are modification sites):HLsEG
纯化工艺
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
浓度
1 mg/ml
实测条带
90kD
修饰
Phospho
克隆性
Polyclonal
同种型
IgG
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抗原&靶点信息
免疫原:
The antiserum was produced against synthesized peptide derived from human ERK3 around the phosphorylation site of Ser189. AA range:155-204
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特异性:
Phospho-ERK 3 (S189) Polyclonal Antibody detects endogenous levels of ERK 3 protein only when phosphorylated at S189.The name of modified sites may be influenced by many factors, such as species (the modified site was not originally found in human samples) and the change of protein sequence (the previous protein sequence is incomplete, and the protein sequence may be prolonged with the development of protein sequencing technology). When naming, we will use the "numbers" in historical reference to keep the sites consistent with the reports. The antibody binds to the following modification sequence (lowercase letters are modification sites):HLsEG
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基因名称:
MAPK6
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蛋白名称:
Mitogen-activated protein kinase 6
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别名:
MAPK6 ;
ERK3 ;
PRKM6 ;
Mitogen-activated protein kinase 6 ;
MAP kinase 6 ;
MAPK 6 ;
Extracellular signal-regulated kinase 3 ;
ERK-3 ;
MAP kinase isoform p97 ;
p97-MAPK
ERK3 ;
PRKM6 ;
Mitogen-activated protein kinase 6 ;
MAP kinase 6 ;
MAPK 6 ;
Extracellular signal-regulated kinase 3 ;
ERK-3 ;
MAP kinase isoform p97 ;
p97-MAPK
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背景:
The protein encoded by this gene is a member of the Ser/Thr protein kinase family, and is most closely related to mitogen-activated protein kinases (MAP kinases). MAP kinases also known as extracellular signal-regulated kinases (ERKs), are activated through protein phosphorylation cascades and act as integration points for multiple biochemical signals. This kinase is localized in the nucleus, and has been reported to be activated in fibroblasts upon treatment with serum or phorbol esters. [provided by RefSeq, Jul 2008],
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功能:
Catalytic activity:ATP + a protein = ADP + a phosphoprotein.,cofactor:Magnesium.,Domain:The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.,enzyme regulation:Activated by threonine and tyrosine phosphorylation.,Function:Phosphorylates microtubule-associated protein 2 (MAP2). May promote entry in the cell cycle.,PTM:Dually phosphorylated on Thr-626 and Tyr-628, which activates the enzyme.,similarity:Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.,similarity:Contains 1 protein kinase domain.,tissue specificity:Highest expression in the skeletal muscle, followed by the brain. Also found in heart, placenta, lung, liver, pancreas, kidney and skin fibroblasts.,
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细胞定位:
Cytoplasm . Nucleus . Translocates to the cytoplasm following interaction with MAPKAPK5. .
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研究领域:
>>IL-17 signaling pathway
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货号: YP0738
规格
价格
货期
数量
200μL
￥4,680.00
现货
0
100μL
￥2,800.00
现货
0
50μL
￥1,500.00
现货
0
加入购物车
已收藏
收藏
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