MuSK (Phospho Tyr755) Rabbit pAb
-YP0510
主要信息
Target
MuSK Phospho Tyr755
Host Species
Rabbit
Reactivity
Human, Mouse, Rat
Applications
WB, ELISA, IHC
MW
97kD (Observed)
Conjugate/Modification
Phospho
货号: YP0510
规格
价格
货期
数量
200μL
￥4,680.00
现货
0
100μL
￥2,800.00
现货
0
50μL
￥1,500.00
现货
0
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详细信息
推荐稀释比
WB 1:500-2000; IHC 1:50-300; ELISA 1:2000-20000
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
特异性
Phospho-MuSK (Y755) Polyclonal Antibody detects endogenous levels of MuSK protein only when phosphorylated at Y755.The name of modified sites may be influenced by many factors, such as species (the modified site was not originally found in human samples) and the change of protein sequence (the previous protein sequence is incomplete, and the protein sequence may be prolonged with the development of protein sequencing technology). When naming, we will use the "numbers" in historical reference to keep the sites consistent with the reports. The antibody binds to the following modification sequence (lowercase letters are modification sites):ADyYK
纯化工艺
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存
-15°C to -25°C/1 year (Do not lower than -25°C)
浓度
1 mg/ml
实测条带
97kD
修饰
Phospho
克隆性
Polyclonal
同种型
IgG
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抗原&靶点信息
免疫原:
Synthesized phospho-peptide around the phosphorylation site of human MuSK (phospho Tyr755)
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特异性:
Phospho-MuSK (Y755) Polyclonal Antibody detects endogenous levels of MuSK protein only when phosphorylated at Y755.The name of modified sites may be influenced by many factors, such as species (the modified site was not originally found in human samples) and the change of protein sequence (the previous protein sequence is incomplete, and the protein sequence may be prolonged with the development of protein sequencing technology). When naming, we will use the "numbers" in historical reference to keep the sites consistent with the reports. The antibody binds to the following modification sequence (lowercase letters are modification sites):ADyYK
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基因名称:
MUSK
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蛋白名称:
Muscle, skeletal receptor tyrosine-protein kinase
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别名:
MUSK ;
Muscle ;
skeletal receptor tyrosine-protein kinase ;
Muscle-specific tyrosine-protein kinase receptor ;
MuSK ;
Muscle-specific kinase receptor
Muscle ;
skeletal receptor tyrosine-protein kinase ;
Muscle-specific tyrosine-protein kinase receptor ;
MuSK ;
Muscle-specific kinase receptor
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背景:
This gene encodes a muscle-specific tyrosine kinase receptor. The encoded protein may play a role in clustering of the acetylcholine receptor in the postsynaptic neuromuscular junction. Mutations in this gene have been associated with congenital myasthenic syndrome. Alternatively spliced transcript variants have been described.[provided by RefSeq , Oct 2009] ,
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功能:
Catalytic activity:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate. ,Disease:Defects in MUSK is a cause of autosomal recessive congenital myasthenic syndrome (CMS) [MIM:608931]. Congenital myasthenic syndromes are inherited disorders of neuromuscular transmission that stem from mutations in presynaptic , synaptic , or postsynaptic proteins. MUSK mutations lead to decreased agrin-dependent AChR aggregation , a critical step in the formation of the neuromuscular junction. ,Function:Receptor tyrosine kinase that is a key mediator of agrin's action and is involved in neuromuscular junction (NMJ) organization. ,online information:MuSK entry ,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family. ,similarity:Contains 1 FZ (frizzled) domain. ,similarity:Contains 1 protein kinase domain. ,similarity:Contains 3 Ig-like C2-type (immunoglobulin-like) domains. ,subunit:Interacts with DOK7 , which probably regulates its activity. ,
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细胞定位:
Cell junction , synapse , postsynaptic cell membrane ; Single-pass type I membrane protein . Colocalizes with acetylcholine receptors (AChR) to the postsynaptic cell membrane of the neuromuscular junction. .
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货号: YP0510
规格
价格
货期
数量
200μL
￥4,680.00
现货
0
100μL
￥2,800.00
现货
0
50μL
￥1,500.00
现货
0
加入购物车
已收藏
收藏
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