Lck BP-1 (Phospho Tyr397) Rabbit pAb
-YP0484
主要信息
Target
Lck BP-1 Phospho Tyr397
Host Species
Rabbit
Reactivity
Human, Mouse, Rat
Applications
WB, IHC
MW
55kD (Observed)
Conjugate/Modification
Phospho
货号: YP0484
规格
价格
货期
数量
200μL
￥4,680.00
现货
0
100μL
￥2,800.00
现货
0
50μL
￥1,500.00
现货
0
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详细信息
推荐稀释比
WB 1:500-2000; IHC 1:50-300
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
特异性
Phospho-Lck BP-1 (Y397) Polyclonal Antibody detects endogenous levels of Lck BP-1 protein only when phosphorylated at Y397.The name of modified sites may be influenced by many factors, such as species (the modified site was not originally found in human samples) and the change of protein sequence (the previous protein sequence is incomplete, and the protein sequence may be prolonged with the development of protein sequencing technology). When naming, we will use the "numbers" in historical reference to keep the sites consistent with the reports. The antibody binds to the following modification sequence (lowercase letters are modification sites):GDyEE
纯化工艺
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存
-15°C to -25°C/1 year (Do not lower than -25°C)
浓度
1 mg/ml
实测条带
55kD
修饰
Phospho
克隆性
Polyclonal
同种型
IgG
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抗原&靶点信息
免疫原:
The antiserum was produced against synthesized peptide derived from human HS1 around the phosphorylation site of Tyr397. AA range:366-415
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特异性:
Phospho-Lck BP-1 (Y397) Polyclonal Antibody detects endogenous levels of Lck BP-1 protein only when phosphorylated at Y397.The name of modified sites may be influenced by many factors, such as species (the modified site was not originally found in human samples) and the change of protein sequence (the previous protein sequence is incomplete, and the protein sequence may be prolonged with the development of protein sequencing technology). When naming, we will use the "numbers" in historical reference to keep the sites consistent with the reports. The antibody binds to the following modification sequence (lowercase letters are modification sites):GDyEE
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基因名称:
HCLS1
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蛋白名称:
Hematopoietic lineage cell-specific protein
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别名:
HCLS1 ;
HS1 ;
Hematopoietic lineage cell-specific protein ;
Hematopoietic cell-specific LYN substrate 1 ;
LckBP1 ;
p75
HS1 ;
Hematopoietic lineage cell-specific protein ;
Hematopoietic cell-specific LYN substrate 1 ;
LckBP1 ;
p75
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背景:
developmental stage:Expressed in early stage of myeloid and erythroid differentiation. ,function:Substrate of the antigen receptor-coupled tyrosine kinase. Plays a role in antigen receptor signaling for both clonal expansion and deletion in lymphoid cells. May also be involved in the regulation of gene expression. ,PTM:Phosphorylated by LYN; rapidly after cross-linking of surface IgM on B-cells. ,similarity:Contains 1 SH3 domain. ,similarity:Contains 4 cortactin repeats. ,subunit:Associates with the SH2 and SH3 domains of LCK. Binding to he LCK SH3 domain occurs constitutively , while binding to the LCK SH2 domain occurs only upon TCR stimulation. A similar binding pattern was observed with LYN , but not with FYN in which the FYN SH2 region associates upon TCR stimulation but the FYN SH3 region does not associate regardless of TCR stimulation. Directly associates with HAX1 , through binding to its C-terminal region. Interacts with HS1BP3. ,tissue specificity:Expressed only in tissues and cells of hematopoietic origin. ,
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功能:
developmental stage:Expressed in early stage of myeloid and erythroid differentiation. ,Function:Substrate of the antigen receptor-coupled tyrosine kinase. Plays a role in antigen receptor signaling for both clonal expansion and deletion in lymphoid cells. May also be involved in the regulation of gene expression. ,PTM:Phosphorylated by LYN; rapidly after cross-linking of surface IgM on B-cells. ,similarity:Contains 1 SH3 domain. ,similarity:Contains 4 cortactin repeats. ,subunit:Associates with the SH2 and SH3 domains of LCK. Binding to he LCK SH3 domain occurs constitutively , while binding to the LCK SH2 domain occurs only upon TCR stimulation. A similar binding pattern was observed with LYN , but not with FYN in which the FYN SH2 region associates upon TCR stimulation but the FYN SH3 region does not associate regardless of TCR stimulation. Directly associates with HAX1 , through binding to its C-terminal region. Interacts with HS1BP3. ,tissue specificity:Expressed only in tissues and cells of hematopoietic origin. ,
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细胞定位:
Membrane ; Peripheral membrane protein . Cytoplasm . Mitochondrion .
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研究领域:
>>Tight junction ;
>>Bacterial invasion of epithelial cells ;
>>Pathogenic Escherichia coli infection ;
>>Shigellosis ;
>>Proteoglycans in cancer
>>Bacterial invasion of epithelial cells ;
>>Pathogenic Escherichia coli infection ;
>>Shigellosis ;
>>Proteoglycans in cancer
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文献引用（{{totalcount}}）
货号: YP0484
规格
价格
货期
数量
200μL
￥4,680.00
现货
0
100μL
￥2,800.00
现货
0
50μL
￥1,500.00
现货
0
加入购物车
已收藏
收藏
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