Erbin (Phospho Tyr1104) Rabbit pAb
-YP0099
主要信息
Target
Erbin Phospho Tyr1104
Host Species
Rabbit
Reactivity
Human, Mouse, Rat
Applications
WB, ELISA
MW
172kD (Observed)
Conjugate/Modification
phosphate
货号: YP0099
规格
价格
货期
数量
200μL
￥4,680.00
现货
0
100μL
￥2,800.00
现货
0
50μL
￥1,500.00
现货
0
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详细信息
推荐稀释比
WB 1:500-1:2000; ELISA 1:10000; Not yet tested in other applications.
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
特异性
Phospho-Erbin (Y1104) Polyclonal Antibody detects endogenous levels of Erbin protein only when phosphorylated at Y1104.The name of modified sites may be influenced by many factors, such as species (the modified site was not originally found in human samples) and the change of protein sequence (the previous protein sequence is incomplete, and the protein sequence may be prolonged with the development of protein sequencing technology). When naming, we will use the "numbers" in historical reference to keep the sites consistent with the reports. The antibody binds to the following modification sequence (lowercase letters are modification sites):GDyLS
纯化工艺
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存
-15°C to -25°C/1 year (Do not lower than -25°C)
浓度
1 mg/ml
实测条带
172kD
修饰
phosphate
克隆性
Polyclonal
同种型
IgG
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抗原&靶点信息
免疫原:
Synthesized phospho-peptide around the phosphorylation site of human Erbin (phospho Tyr1104)
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特异性:
Phospho-Erbin (Y1104) Polyclonal Antibody detects endogenous levels of Erbin protein only when phosphorylated at Y1104.The name of modified sites may be influenced by many factors, such as species (the modified site was not originally found in human samples) and the change of protein sequence (the previous protein sequence is incomplete, and the protein sequence may be prolonged with the development of protein sequencing technology). When naming, we will use the "numbers" in historical reference to keep the sites consistent with the reports. The antibody binds to the following modification sequence (lowercase letters are modification sites):GDyLS
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基因名称:
ERBB2IP ERBIN KIAA1225 LAP2
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蛋白名称:
Erbin Polyclonal Antibody
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别名:
ERBB2IP ;
ERBIN ;
KIAA1225 ;
LAP2 ;
Protein LAP2 ;
Densin-180-like protein ;
Erbb2-interacting protein ;
Erbin
ERBIN ;
KIAA1225 ;
LAP2 ;
Protein LAP2 ;
Densin-180-like protein ;
Erbb2-interacting protein ;
Erbin
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背景:
This gene is a member of the leucine-rich repeat and PDZ domain (LAP) family. The encoded protein contains 17 leucine-rich repeats and one PDZ domain. It binds to the unphosphorylated form of the ERBB2 protein and regulates ERBB2 function and localization. It has also been shown to affect the Ras signaling pathway by disrupting Ras-Raf interaction. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq , Nov 2011] ,
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功能:
Function:Acts as an adapter for the receptor ERBB2 , in epithelia. By binding the unphosphorylated 'Tyr-1248' of receptor ERBB2 , it may contribute to stabilize this unphosphorylated state. ,sequence Caution:Contaminating sequence. Potential poly-A sequence. ,similarity:Belongs to the LAP (LRR and PDZ) protein family. ,similarity:Contains 1 PDZ (DHR) domain. ,similarity:Contains 17 LRR (leucine-rich) repeats. ,subcellular location:Found in hemidesmosomes , which are cell-substrate adhesion complexes in stratified epithelia. In transfected cells , either diffusely distributed over the cytoplasm or concentrated at the basolateral membrane. ,subunit:Interacts with ERBB2 , BPAG1 and ITGB4. May favor the localization of ERBB2 , by restricting its presence to the basolateral membrane of epithelial cells. Also found to interact with ARVCF and delta catenin. ,tissue specificity:Highly expressed in brain , heart , kidney , muscle and stomach , followed by liver , spleen and intestine. ,
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细胞定位:
Cell junction , hemidesmosome . Nucleus membrane . Basolateral cell membrane . Found in hemidesmosomes , which are cell-substrate adhesion complexes in stratified epithelia. In transfected cells , either diffusely distributed over the cytoplasm or concentrated at the basolateral membrane. Colocalizes with the adrenergic receptors , ADREN1A and ADREN1B , at the nuclear membrane of cardiac myocytes (By similarity) . .
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研究领域:
>>NOD-like receptor signaling pathway
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货号: YP0099
规格
价格
货期
数量
200μL
￥4,680.00
现货
0
100μL
￥2,800.00
现货
0
50μL
￥1,500.00
现货
0
加入购物车
已收藏
收藏
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