Synaptotagmin 1/2 (Phospho Thr202/199) Rabbit pAb
-YP0587
主要信息
Target
Synaptotagmin 1/2 Phospho Thr202/199
Host Species
Rabbit
Reactivity
Human, Mouse, Rat
Applications
WB, IHC, IF, ELISA
MW
60kD (Observed)
Conjugate/Modification
Phospho
货号: YP0587
规格
价格
货期
数量
200μL
￥4,680.00
现货
0
100μL
￥2,800.00
现货
0
50μL
￥1,500.00
现货
0
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详细信息
推荐稀释比
WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:40000; IF 1:50-200
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
特异性
This antibody detects endogenous levels of Synaptotagmin 1/2 only when phosphorylated at Human:T202/199, Mouse:T201/202, Rat:T201/202..The name of modified sites may be influenced by many factors, such as species (the modified site was not originally found in human samples) and the change of protein sequence (the previous protein sequence is incomplete, and the protein sequence may be prolonged with the development of protein sequencing technology). When naming, we will use the "numbers" in historical reference to keep the sites consistent with the reports. The antibody binds to the following modification sequence (lowercase letters are modification sites):RKtLN
纯化工艺
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
浓度
1 mg/ml
实测条带
60kD
修饰
Phospho
克隆性
Polyclonal
同种型
IgG
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Synaptotagmin 1/2 (Phospho Thr202/199) Rabbit pAb
YP0587
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ELISA Kits
Total Synaptotagmin Cell-Based Colorimetric ELISA Kit
KA4298C
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ELISA Kits
Synaptotagmin (Phospho Thr202) Cell-Based Colorimetric ELISA Kit
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ELISA Kits
Synaptotagmin (Phospho Ser309) Cell-Based Colorimetric ELISA Kit
KA1185C
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抗原&靶点信息
免疫原:
The antiserum was produced against synthesized peptide derived from human Synaptotagmin around the phosphorylation site of Thr202. AA range:176-225
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特异性:
This antibody detects endogenous levels of Synaptotagmin 1/2 only when phosphorylated at Human:T202/199, Mouse:T201/202, Rat:T201/202..The name of modified sites may be influenced by many factors, such as species (the modified site was not originally found in human samples) and the change of protein sequence (the previous protein sequence is incomplete, and the protein sequence may be prolonged with the development of protein sequencing technology). When naming, we will use the "numbers" in historical reference to keep the sites consistent with the reports. The antibody binds to the following modification sequence (lowercase letters are modification sites):RKtLN
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基因名称:
SYT1/SYT2
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蛋白名称:
Synaptotagmin-1/2
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别名:
SYT1 ;
SVP65 ;
SYT ;
Synaptotagmin-1 ;
Synaptotagmin I ;
SytI ;
p65 ;
SYT2 ;
Synaptotagmin-2 ;
Synaptotagmin II ;
SytII
SVP65 ;
SYT ;
Synaptotagmin-1 ;
Synaptotagmin I ;
SytI ;
p65 ;
SYT2 ;
Synaptotagmin-2 ;
Synaptotagmin II ;
SytII
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数据库链接:
背景:
The synaptotagmins are integral membrane proteins of synaptic vesicles thought to serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis. Calcium binding to synaptotagmin-1 participates in triggering neurotransmitter release at the synapse (Fernandez-Chacon et al., 2001 [PubMed 11242035]).[supplied by OMIM, Jul 2010],
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功能:
cofactor:Binds 3 calcium ions per subunit. The ions are bound to the C2 domains.,Domain:The first C2 domain mediates Ca(2+)-dependent phospholipid binding.,Domain:The second C2 domain mediates interaction with SV2A and STN2.,Function:May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. A Ca(2+)-dependent interaction between synaptotagmin and putative receptors for activated protein kinase C has also been reported. It can bind to at least three additional proteins in a Ca(2+)-independent manner; these are neurexins, syntaxin and AP2.,similarity:Belongs to the synaptotagmin family.,similarity:Contains 2 C2 domains.,subcellular location:Synaptic vesicles and chromaffin granules.,subunit:Homotetramer (Probable). Interacts with SCAMP5, STN2, SV2A, SV2B, SV2C and RIMS1. Forms a complex with SV2B, syntaxin 1 and SNAP25.,
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细胞定位:
Cytoplasmic vesicle, secretory vesicle membrane ; Single-pass membrane protein . Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane ; Single-pass membrane protein . Cytoplasmic vesicle, secretory vesicle, chromaffin granule membrane ; Single-pass membrane protein . Cytoplasm .
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组织表达:
研究领域:
>>Synaptic vesicle cycle
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货号: YP0587
规格
价格
货期
数量
200μL
￥4,680.00
现货
0
100μL
￥2,800.00
现货
0
50μL
￥1,500.00
现货
0
加入购物车
已收藏
收藏
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