The antiserum was produced against synthesized peptide derived from human PDCD4 around the phosphorylation site of Ser67. AA range:33-82

Phospho-Pdcd-4 (S67) Polyclonal Antibody detects endogenous levels of Pdcd-4 protein only when phosphorylated at S67.The name of modified sites may be influenced by many factors, such as species (the modified site was not originally found in human samples) and the change of protein sequence (the previous protein sequence is incomplete, and the protein sequence may be prolonged with the development of protein sequencing technology). When naming, we will use the "numbers" in historical reference to keep the sites consistent with the reports. The antibody binds to the following modification sequence (lowercase letters are modification sites):KNsSR

PDCD4

Programmed cell death protein 4

PDCD4 ;
H731 ;
Programmed cell death protein 4 ;
Neoplastic transformation inhibitor protein ;
Nuclear antigen H731-like ;
Protein 197/15a

This gene is a tumor suppressor and encodes a protein that binds to the eukaryotic translation initiation factor 4A1 and inhibits its function by preventing RNA binding. Alternative splicing results in multiple transcript variants. [provided by RefSeq , Dec 2010] ,

Caution:The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data. ,Disease:Loss of expression correlated with tumor progression of lung and colon carcinoma. ,Domain:Binds EIF4A1 via the MA3 domains. ,Function:Tumor suppressor. Inhibits tumor promoter-induced neoplastic transformation. Down-regulates the expression of MAP4K1 , thus inhibiting events important in driving invasion , namely , MAPK85 activation and consequent JUN-dependent transcription. May play a role in apoptosis. Inhibits the helicase activity of EIF4A and cap-dependent translation. Binds RNA. ,induction:IL2 stimulation inhibits expression , while IL12 increases expression. ,sequence Caution:Contaminating sequence. Potential poly-A sequence. ,similarity:Belongs to the PDCD4 family. ,similarity:Contains 2 MI domains. ,subcellular location:Shuttles between the nucleus and cytoplasm. Predominantly nuclear under normal growth conditions. Exported from the nucleus in the absence of serum. ,subunit:Interacts with EIF4A1 and EIF4A2. ,tissue specificity:Up-regulated in proliferative cells. Highly expressed in epithelial cells of the mammary gland. ,

Nucleus . Cytoplasm . Shuttles between the nucleus and cytoplasm (By similarity) . Predominantly nuclear under normal growth conditions , and when phosphorylated at Ser-457 (PubMed:16357133) . .

>>Proteoglycans in cancer ;
>>MicroRNAs in cancer