PKA IIβ reg (Phospho Ser113) Rabbit pAb
-YP0360
主要信息
Target
PKA IIβ reg Phospho Ser113
Host Species
Rabbit
Reactivity
Human, Mouse, Rat, Monkey
Applications
WB, IHC, IF, ELISA
MW
46kD (Observed)
Conjugate/Modification
Phospho
货号: YP0360
规格
价格
货期
数量
200μL
￥4,680.00
现货
0
100μL
￥2,800.00
现货
0
50μL
￥1,500.00
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0
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详细信息
推荐稀释比
WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:10000; IF 1:50-200
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
特异性
Phospho-PKA IIβ reg (S113) Polyclonal Antibody detects endogenous levels of PKA IIβ reg protein only when phosphorylated at S113.The name of modified sites may be influenced by many factors, such as species (the modified site was not originally found in human samples) and the change of protein sequence (the previous protein sequence is incomplete, and the protein sequence may be prolonged with the development of protein sequencing technology). When naming, we will use the "numbers" in historical reference to keep the sites consistent with the reports. The antibody binds to the following modification sequence (lowercase letters are modification sites):RAsVC
纯化工艺
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存
-15°C to -25°C/1 year (Do not lower than -25°C)
浓度
1 mg/ml
实测条带
46kD
修饰
Phospho
克隆性
Polyclonal
同种型
IgG
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PKA IIβ reg Rabbit pAb
YT3745
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Primary Antibodies
PKA IIβ reg (Phospho Ser113) Rabbit pAb
YP0360
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ELISA Kits
Total PKA-R2β Cell-Based Colorimetric ELISA Kit
KA4235C
预览→
ELISA Kits
PKA-R2β (Phospho Ser113) Cell-Based Colorimetric ELISA Kit
KA1470C
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抗原&靶点信息
免疫原:
The antiserum was produced against synthesized peptide derived from human PKA-R2 beta around the phosphorylation site of Ser113. AA range:79-128
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特异性:
Phospho-PKA IIβ reg (S113) Polyclonal Antibody detects endogenous levels of PKA IIβ reg protein only when phosphorylated at S113.The name of modified sites may be influenced by many factors, such as species (the modified site was not originally found in human samples) and the change of protein sequence (the previous protein sequence is incomplete, and the protein sequence may be prolonged with the development of protein sequencing technology). When naming, we will use the "numbers" in historical reference to keep the sites consistent with the reports. The antibody binds to the following modification sequence (lowercase letters are modification sites):RAsVC
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基因名称:
PRKAR2B
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蛋白名称:
cAMP-dependent protein kinase type II-beta regulatory subunit
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别名:
PRKAR2B ;
cAMP-dependent protein kinase type II-beta regulatory subunit
cAMP-dependent protein kinase type II-beta regulatory subunit
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背景:
cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase , which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. The protein encoded by this gene is one of the regulatory subunits. This subunit can be phosphorylated by the activated catalytic subunit. This subunit has been shown to interact with and suppress the transcriptional activity of the cAMP responsive element binding protein 1 (CREB1) in activ
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功能:
Function:Type II regulatory chains mediate membrane association by binding to anchoring proteins , including the MAP2 kinase. ,PTM:Phosphorylated by the activated catalytic chain. ,similarity:Belongs to the cAMP-dependent kinase regulatory chain family. ,similarity:Contains 2 cyclic nucleotide-binding domains. ,subunit:The inactive form of the enzyme is composed of two regulatory chains and two catalytic chains. Activation by cAMP produces two active catalytic monomers and a regulatory dimer that binds four cAMP molecules. ,tissue specificity:Four types of regulatory chains are found: I-alpha , I-beta , II-alpha , and II-beta. Their expression varies among tissues and is in some cases constitutive and in others inducible. ,
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细胞定位:
Cytoplasm . Cell membrane . Colocalizes with PJA2 in the cytoplasm and at the cell membrane.
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研究领域:
>>Insulin signaling pathway
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货号: YP0360
规格
价格
货期
数量
200μL
￥4,680.00
现货
0
100μL
￥2,800.00
现货
0
50μL
￥1,500.00
现货
0
加入购物车
已收藏
收藏
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