PKD2 (Phospho Ser876) Rabbit pAb
-YP0341
主要信息
Target
PKD2 Phospho Ser876
Host Species
Rabbit
Reactivity
Human, Mouse, Rat
Applications
WB, IHC, IF, ELISA
MW
96kD (Observed)
Conjugate/Modification
Phospho
货号: YP0341
规格
价格
货期
数量
200μL
￥4,680.00
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0
100μL
￥2,800.00
现货
0
50μL
￥1,500.00
现货
0
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详细信息
推荐稀释比
WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:40000; IF 1:50-200
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
特异性
Phospho-PKD2 (S876) Polyclonal Antibody detects endogenous levels of PKD2 protein only when phosphorylated at S876.The name of modified sites may be influenced by many factors, such as species (the modified site was not originally found in human samples) and the change of protein sequence (the previous protein sequence is incomplete, and the protein sequence may be prolonged with the development of protein sequencing technology). When naming, we will use the "numbers" in historical reference to keep the sites consistent with the reports. The antibody binds to the following modification sequence (lowercase letters are modification sites):RIsVL
纯化工艺
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存
-15°C to -25°C/1 year (Do not lower than -25°C)
浓度
1 mg/ml
实测条带
96kD
修饰
Phospho
克隆性
Polyclonal
同种型
IgG
相关产品
Primary Antibodies
PKD2 Rabbit pAb
YT3773
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Primary Antibodies
PKD2 (Phospho Ser876) Rabbit pAb
YP0341
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ELISA Kits
Total PKD2 Cell-Based Colorimetric ELISA Kit
KA4244C
预览→
ELISA Kits
PKD2 (Phospho Ser876) Cell-Based Colorimetric ELISA Kit
KA1415C
预览→
抗原&靶点信息
免疫原:
The antiserum was produced against synthesized peptide derived from human PKD2 around the phosphorylation site of Ser876. AA range:829-878
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特异性:
Phospho-PKD2 (S876) Polyclonal Antibody detects endogenous levels of PKD2 protein only when phosphorylated at S876.The name of modified sites may be influenced by many factors, such as species (the modified site was not originally found in human samples) and the change of protein sequence (the previous protein sequence is incomplete, and the protein sequence may be prolonged with the development of protein sequencing technology). When naming, we will use the "numbers" in historical reference to keep the sites consistent with the reports. The antibody binds to the following modification sequence (lowercase letters are modification sites):RIsVL
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基因名称:
PRKD2
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蛋白名称:
Serine/threonine-protein kinase D2
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别名:
PRKD2 ;
PKD2 ;
HSPC187 ;
Serine/threonine-protein kinase D2 ;
nPKC-D2
PKD2 ;
HSPC187 ;
Serine/threonine-protein kinase D2 ;
nPKC-D2
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背景:
The protein encoded by this gene belongs to the protein kinase D (PKD) family of serine/threonine protein kinases. This kinase can be activated by phorbol esters as well as by gastrin via the cholecystokinin B receptor (CCKBR) in gastric cancer cells. It can bind to diacylglycerol (DAG) in the trans-Golgi network (TGN) and may regulate basolateral membrane protein exit from TGN. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq , Jul 2008] ,
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功能:
Catalytic activity:ATP + a protein = ADP + a phosphoprotein. ,enzyme regulation:Activated by diacylglycerol and phorbol esters. ,Function:Calcium-independent , phospholipid-dependent , serine- and threonine-specific protein kinase. ,PTM:Autophosphorylated. Phorbol esters stimulates autophosphorylation. Phosphorylation of Ser-876 correlates with the activation status of the kinase. ,similarity:Belongs to the protein kinase superfamily. ,similarity:Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PKD subfamily. ,similarity:Contains 1 PH domain. ,similarity:Contains 1 protein kinase domain. ,similarity:Contains 2 phorbol-ester/DAG-type zinc fingers. ,tissue specificity:Widely expressed. ,
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细胞定位:
Cytoplasm . Cell membrane . Nucleus . Golgi apparatus , trans-Golgi network . Translocation to the cell membrane is required for kinase activation. Accumulates in the nucleus upon CK1-mediated phosphorylation after activation of G-protein-coupled receptors. Nuclear accumulation is regulated by blocking nuclear export of active PRKD2 rather than by increasing import. .
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组织表达:
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研究领域:
>>Rap1 signaling pathway ;
>>Aldosterone synthesis and secretion ;
>>Chemical carcinogenesis - reactive oxygen species
>>Aldosterone synthesis and secretion ;
>>Chemical carcinogenesis - reactive oxygen species
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信号通路
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货号: YP0341
规格
价格
货期
数量
200μL
￥4,680.00
现货
0
100μL
￥2,800.00
现货
0
50μL
￥1,500.00
现货
0
加入购物车
已收藏
收藏
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