Synthesized phosho peptide around human RIP (Ser166)

This antibody detects endogenous levels of Human RIP (phospho-Ser166)

RIPK1 RIP RIP1

RIP (Ser166)

Receptor-interacting serine/threonine-protein kinase 1 ;
Cell death protein RIP ;
Receptor-interacting protein 1 ;
RIP-1 ;
Serine/threonine-protein kinase RIP ;

This gene encodes a member of the receptor-interacting protein (RIP) family of serine/threonine protein kinases. The encoded protein plays a role in inflammation and cell death in response to tissue damage , pathogen recognition , and as part of developmental regulation. RIPK1/RIPK3 kinase-mediated necrosis is referred to as necroptosis. Genetic disruption of this gene in mice results in death shortly after birth. [provided by RefSeq , Aug 2017]

Catalytic activity:ATP + a protein = ADP + a phosphoprotein. ,Function:Promotes apoptosis and activation of NF-kappa-B. Required for TNFRSF1A mediated activation of NF-kappa-B. ,PTM:Autophosphorylated on serine and threonine residues. ,PTM:Proteolytically cleaved by caspase-8 during TNF-induced apoptosis. Cleavage abolishes NF-kappa-B activation and enhances pro-apototic signaling through the TRADD-FADD interaction. ,similarity:Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. ,similarity:Contains 1 death domain. ,similarity:Contains 1 protein kinase domain. ,subunit:Binds to the death domain of TNFRSF6 and TRADD. Is recruited by TRADD to TNFRSF1A in a TNF-dependent process. Binds RIPK3 , UBCE7IP1 isoform 3 (ZIN) , EGFR , IKBKG , TRAF1 , TRAF2 and TRAF3. Interacts with BNLF1. Interacts with SQSTM1 upon TNF-alpha stimulation. May interacts with MAVS/IPS1. ,

Cytoplasm . Cell membrane .

>>NF-kappa B signaling pathway ;
>>Apoptosis ;
>>Necroptosis ;
>>Toll-like receptor signaling pathway ;
>>NOD-like receptor signaling pathway ;
>>RIG-I-like receptor signaling pathway ;
>>Cytosolic DNA-sensing pathway ;
>>TNF signaling pathway ;
>>Alcoholic liver disease ;
>>Pathogenic Escherichia coli infection ;
>>Shigellosis ;
>>Salmonella infection ;
>>Hepatitis C ;
>>Human cytomegalovirus infection ;
>>Epstein-Barr virus infection ;
>>Human immunodeficiency virus 1 infection