MLKL (Phospho Ser358) Rabbit pAb
-YP1244
主要信息
Target
MLKL Phospho Ser358
Host Species
Rabbit
Reactivity
Human
Applications
IHC, IF
MW
55kD (Observed)
Conjugate/Modification
phosphate
货号: YP1244
规格
价格
货期
数量
200μL
￥4,680.00
现货
0
100μL
￥2,800.00
现货
0
50μL
￥1,500.00
现货
0
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详细信息
推荐稀释比
IHC 1:100-500; IF/ICC1:100-500
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
特异性
This antibody detects endogenous phospho levels of MLKL (phospho S358)
纯化工艺
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
储存
-15°C to -25°C/1 year (Do not lower than -25°C)
浓度
1 mg/ml
实测条带
55kD
修饰
phosphate
克隆性
Polyclonal
同种型
IgG
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抗原&靶点信息
免疫原:
Synthesized peptide derived from human MLKL (phospho S358)
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特异性:
This antibody detects endogenous phospho levels of MLKL (phospho S358)
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基因名称:
MLKL
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蛋白名称:
MLKL (phospho S358)
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别名:
Mixed lineage kinase domain-like protein
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背景:
This gene belongs to the protein kinase superfamily. The encoded protein contains a protein kinase-like domain; however , is thought to be inactive because it lacks several residues required for activity. This protein plays a critical role in tumor necrosis factor (TNF) -induced necroptosis , a programmed cell death process , via interaction with receptor-interacting protein 3 (RIP3) , which is a key signaling molecule in necroptosis pathway. Inhibitor studies and knockdown of this gene inhibited TNF-induced necrosis. High levels of this protein and RIP3 are associated with inflammatory bowel disease in children. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq , Sep 2015] ,
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功能:
Domain:The protein kinase domain is predicted to be catalytically inactive. ,similarity:Belongs to the protein kinase superfamily. ,similarity:Contains 1 protein kinase domain. ,
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细胞定位:
Cytoplasm . Cell membrane . Nucleus . Localizes to the cytoplasm and translocates to the plasma membrane on necroptosis induction (PubMed:24316671) . Localizes to the nucleus in response to orthomyxoviruses infection (By similarity) . .
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组织表达:
研究领域:
>>Necroptosis ;
>>TNF signaling pathway ;
>>Salmonella infection
>>TNF signaling pathway ;
>>Salmonella infection
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信号通路
文献引用（{{totalcount}}）
货号: YP1244
规格
价格
货期
数量
200μL
￥4,680.00
现货
0
100μL
￥2,800.00
现货
0
50μL
￥1,500.00
现货
0
加入购物车
已收藏
收藏
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