Claudin-3 (Phospho Tyr219) Rabbit pAb
-YP0464
主要信息
Target
Claudin 3 Phospho Tyr219
Host Species
Rabbit
Reactivity
Human, Mouse, Rat
Applications
WB, IHC, IF, ELISA
MW
28kD (Observed)
Conjugate/Modification
Phospho
货号: YP0464
规格
价格
货期
数量
200μL
￥4,680.00
现货
0
100μL
￥2,800.00
现货
0
50μL
￥1,500.00
现货
0
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详细信息
推荐稀释比
WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:5000; IF 1:50-200
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
特异性
Phospho-Claudin-3 (Y219) Polyclonal Antibody detects endogenous levels of Claudin-3 protein only when phosphorylated at Y219.The name of modified sites may be influenced by many factors, such as species (the modified site was not originally found in human samples) and the change of protein sequence (the previous protein sequence is incomplete, and the protein sequence may be prolonged with the development of protein sequencing technology). When naming, we will use the "numbers" in historical reference to keep the sites consistent with the reports. The antibody binds to the following modification sequence (lowercase letters are modification sites):RKDyV
纯化工艺
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
浓度
1 mg/ml
实测条带
28kD
修饰
Phospho
克隆性
Polyclonal
同种型
IgG
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抗原&靶点信息
免疫原:
The antiserum was produced against synthesized peptide derived from human Claudin 3 around the phosphorylation site of Tyr219. AA range:171-220
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特异性:
Phospho-Claudin-3 (Y219) Polyclonal Antibody detects endogenous levels of Claudin-3 protein only when phosphorylated at Y219.The name of modified sites may be influenced by many factors, such as species (the modified site was not originally found in human samples) and the change of protein sequence (the previous protein sequence is incomplete, and the protein sequence may be prolonged with the development of protein sequencing technology). When naming, we will use the "numbers" in historical reference to keep the sites consistent with the reports. The antibody binds to the following modification sequence (lowercase letters are modification sites):RKDyV
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基因名称:
CLDN3
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蛋白名称:
Claudin-3
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别名:
CLDN3 ;
C7orf1 ;
CPETR2 ;
Claudin-3 ;
Clostridium perfringens enterotoxin receptor 2 ;
CPE-R 2 ;
CPE-receptor 2 ;
Rat ventral prostate.1 protein homolog ;
hRVP1
C7orf1 ;
CPETR2 ;
Claudin-3 ;
Clostridium perfringens enterotoxin receptor 2 ;
CPE-R 2 ;
CPE-receptor 2 ;
Rat ventral prostate.1 protein homolog ;
hRVP1
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背景:
Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. The protein encoded by this intronless gene, a member of the claudin family, is an integral membrane protein and a component of tight junction strands. It is also a low-affinity receptor for Clostridium perfringens enterotoxin, and shares aa sequence similarity with a putative apoptosis-related protein found in rat. [provided by RefSeq, Jul 2008],
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功能:
Disease:Haploinsufficiency of CLDN3 may be the cause of certain cardiovascular and musculo-skeletal abnormalities observed in Williams-Beuren syndrome (WBS), a rare developmental disorder. It is a contiguous gene deletion syndrome involving genes from chromosome band 7q11.23.,Function:Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.,similarity:Belongs to the claudin family.,subunit:Can form homo- and heteropolymers with other CLDN. Homopolymers interact with CLDN1 and CLDN2 homopolymers. Directly interacts with TJP1/ZO-1, TJP2/ZO-2 and TJP3/ZO-3.,
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细胞定位:
Cell junction, tight junction . Cell membrane ; Multi-pass membrane protein .
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组织表达:
研究领域:
>>Cell adhesion molecules ;
>>Tight junction ;
>>Leukocyte transendothelial migration ;
>>Pathogenic Escherichia coli infection ;
>>Hepatitis C
>>Tight junction ;
>>Leukocyte transendothelial migration ;
>>Pathogenic Escherichia coli infection ;
>>Hepatitis C
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信号通路
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货号: YP0464
规格
价格
货期
数量
200μL
￥4,680.00
现货
0
100μL
￥2,800.00
现货
0
50μL
￥1,500.00
现货
0
加入购物车
已收藏
收藏
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