YAP (Phospho Ser127) Rabbit pAb
-YP0708
主要信息
Target
YAP Phospho Ser127
Host Species
Rabbit
Reactivity
Human, Mouse, Rat, Monkey
Applications
WB, IHC, IF, ELISA
MW
65kD (Observed)
Conjugate/Modification
phosphate
货号: YP0708
规格
价格
货期
数量
200μL
￥4,680.00
现货
0
100μL
￥2,800.00
现货
0
50μL
￥1,500.00
现货
0
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详细信息
推荐稀释比
IF 1:50-200; WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:40000; Not yet tested in other applications
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
特异性
Phospho-YAP (S127) Polyclonal Antibody detects endogenous levels of YAP protein only when phosphorylated at S127.The name of modified sites may be influenced by many factors, such as species (the modified site was not originally found in human samples) and the change of protein sequence (the previous protein sequence is incomplete, and the protein sequence may be prolonged with the development of protein sequencing technology). When naming, we will use the "numbers" in historical reference to keep the sites consistent with the reports. The antibody binds to the following modification sequence (lowercase letters are modification sites):AHsSP
纯化工艺
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存
-15°C to -25°C/1 year (Do not lower than -25°C)
浓度
1 mg/ml
实测条带
65kD
修饰
phosphate
克隆性
Polyclonal
同种型
IgG
相关产品
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Primary Antibodies
YAP (Phospho Ser127) Rabbit pAb
YP0708
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ELISA Kits
Total YAP Cell-Based Colorimetric ELISA Kit
KA3612C
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ELISA Kits
YAP (Phospho Ser127) Cell-Based Colorimetric ELISA Kit
KA1392C
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抗原&靶点信息
免疫原:
The antiserum was produced against synthesized peptide derived from human YAP around the phosphorylation site of Ser127. AA range:93-142
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特异性:
Phospho-YAP (S127) Polyclonal Antibody detects endogenous levels of YAP protein only when phosphorylated at S127.The name of modified sites may be influenced by many factors, such as species (the modified site was not originally found in human samples) and the change of protein sequence (the previous protein sequence is incomplete, and the protein sequence may be prolonged with the development of protein sequencing technology). When naming, we will use the "numbers" in historical reference to keep the sites consistent with the reports. The antibody binds to the following modification sequence (lowercase letters are modification sites):AHsSP
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基因名称:
YAP1
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蛋白名称:
Yorkie homolog
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别名:
YAP1 ;
YAP65 ;
Yorkie homolog ;
65 kDa Yes-associated protein ;
YAP65
YAP65 ;
Yorkie homolog ;
65 kDa Yes-associated protein ;
YAP65
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背景:
This gene encodes a downstream nuclear effector of the Hippo signaling pathway which is involved in development , growth , repair , and homeostasis. This gene is known to play a role in the development and progression of multiple cancers as a transcriptional regulator of this signaling pathway and may function as a potential target for cancer treatment. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq , Aug 2013] ,
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功能:
PTM:Phosphorylated upon DNA damage , probably by ATM or ATR. ,similarity:Contains 1 WW domain. ,subunit:Binds to the SH3 domain of the YES kinase. Binds to WBP1 and WBP2. Binds , in vitro , through the WW1 domain , to neural isoforms of ENAH that contain the PPSY motif. ,
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细胞定位:
Cytoplasm . Nucleus . Both phosphorylation and cell density can regulate its subcellular localization (PubMed:18158288 , PubMed:20048001) . Phosphorylation sequesters it in the cytoplasm by inhibiting its translocation into the nucleus (PubMed:18158288 , PubMed:20048001) . At low density , predominantly nuclear and is translocated to the cytoplasm at high density (PubMed:18158288 , PubMed:20048001 , PubMed:25849865) . PTPN14 induces translocation from the nucleus to the cytoplasm (PubMed:22525271) . Localized mainly to the nucleus in the early stages of embryo development with expression becoming evident in the cytoplasm at the blastocyst and epiblast stages (By similarity) . .
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研究领域:
>>Hippo signaling pathway ;
>>Hippo signaling pathway - multiple species
>>Hippo signaling pathway - multiple species
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信号通路
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货号: YP0708
规格
价格
货期
数量
200μL
￥4,680.00
现货
0
100μL
￥2,800.00
现货
0
50μL
￥1,500.00
现货
0
加入购物车
已收藏
收藏
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