ATF-1 (Phospho Ser63) Rabbit pAb
-YP0294
主要信息
Target
ATF-1 Phospho Ser63
Host Species
Rabbit
Reactivity
Human, Mouse
Applications
WB, ELISA
MW
29kD (Observed)
Conjugate/Modification
Phospho
货号: YP0294
规格
价格
货期
数量
200μL
￥4,680.00
现货
0
100μL
￥2,800.00
现货
0
50μL
￥1,500.00
现货
0
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详细信息
推荐稀释比
WB 1:500-1:2000; ELISA 1:5000; Not yet tested in other applications.
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
特异性
Phospho-ATF-1 (S63) Polyclonal Antibody detects endogenous levels of ATF-1 protein only when phosphorylated at S63.The name of modified sites may be influenced by many factors, such as species (the modified site was not originally found in human samples) and the change of protein sequence (the previous protein sequence is incomplete, and the protein sequence may be prolonged with the development of protein sequencing technology). When naming, we will use the "numbers" in historical reference to keep the sites consistent with the reports. The antibody binds to the following modification sequence (lowercase letters are modification sites):RPsYR
纯化工艺
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存
-15°C to -25°C/1 year (Do not lower than -25°C)
浓度
1 mg/ml
实测条带
29kD
修饰
Phospho
克隆性
Polyclonal
同种型
IgG
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抗原&靶点信息
免疫原:
The antiserum was produced against synthesized peptide derived from human ATF1 around the phosphorylation site of Ser63. AA range:31-80
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特异性:
Phospho-ATF-1 (S63) Polyclonal Antibody detects endogenous levels of ATF-1 protein only when phosphorylated at S63.The name of modified sites may be influenced by many factors, such as species (the modified site was not originally found in human samples) and the change of protein sequence (the previous protein sequence is incomplete, and the protein sequence may be prolonged with the development of protein sequencing technology). When naming, we will use the "numbers" in historical reference to keep the sites consistent with the reports. The antibody binds to the following modification sequence (lowercase letters are modification sites):RPsYR
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基因名称:
ATF1
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蛋白名称:
Cyclic AMP-dependent transcription factor ATF-1
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别名:
ATF1 ;
Cyclic AMP-dependent transcription factor ATF-1 ;
cAMP-dependent transcription factor ATF-1 ;
Activating transcription factor 1 ;
Protein TREB36
Cyclic AMP-dependent transcription factor ATF-1 ;
cAMP-dependent transcription factor ATF-1 ;
Activating transcription factor 1 ;
Protein TREB36
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背景:
activating transcription factor 1 (ATF1) Homo sapiens This gene encodes an activating transcription factor , which belongs to the ATF subfamily and bZIP (basic-region leucine zipper) family. It influences cellular physiologic processes by regulating the expression of downstream target genes , which are related to growth , survival , and other cellular activities. This protein is phosphorylated at serine 63 in its kinase-inducible domain by serine/threonine kinases , cAMP-dependent protein kinase A , calmodulin-dependent protein kinase I/II , mitogen- and stress-activated protein kinase and cyclin-dependent kinase 3 (cdk-3) . Its phosphorylation enhances its transactivation and transcriptional activities , and enhances cell transformation. Fusion of this gene and FUS on chromosome 16 or EWSR1 on chromosome 22 induced by translocation generates chimeric proteins in angiomatoid fibrous histiocytoma and clear cell sarcoma. This gene has a pseudogene on chro
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功能:
Disease:A chromosomal aberration involving ATF1 is associated with angiomatoid fibrous histiocytoma (AFH) [MIM:612160]. Translocation t (12;16) (q13;p11.2) with FUS generates a chimeric ATF1/FUS protein. ,Disease:A chromosomal aberration involving ATF1 is associated with angiomatoid fibrous histiocytoma (AFH) [MIM:612160]. Translocation t (12;22) (q13;q12) with EWSR1 generates a chimeric ATF1/EWSR1 protein. ,Function:This protein binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3') , a sequence present in many viral and cellular promoters. Binds to the Tax-responsive element (TRE) of HTLV-I. Mediates PKA-induced stimulation of CRE-reporter genes. ,similarity:Belongs to the bZIP family. ATF subfamily. ,similarity:Contains 1 bZIP domain. ,similarity:Contains 1 KID (kinase-inducible) domain. ,subunit:Binds DNA as a dimer. ,
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细胞定位:
Nucleus .
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组织表达:
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研究领域:
>>Aldosterone synthesis and secretion ;
>>Transcriptional misregulation in cancer
>>Transcriptional misregulation in cancer
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信号通路
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货号: YP0294
规格
价格
货期
数量
200μL
￥4,680.00
现货
0
100μL
￥2,800.00
现货
0
50μL
￥1,500.00
现货
0
加入购物车
已收藏
收藏
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