The antiserum was produced against synthesized peptide derived from human MAP2K7 around the phosphorylation site of Thr275. AA range:241-290

Phospho-MEK-7 (T275) Polyclonal Antibody detects endogenous levels of MEK-7 protein only when phosphorylated at T275.The name of modified sites may be influenced by many factors, such as species (the modified site was not originally found in human samples) and the change of protein sequence (the previous protein sequence is incomplete, and the protein sequence may be prolonged with the development of protein sequencing technology). When naming, we will use the "numbers" in historical reference to keep the sites consistent with the reports. The antibody binds to the following modification sequence (lowercase letters are modification sites):AKtRS

MAP2K7

Dual specificity mitogen-activated protein kinase kinase 7

MAP2K7 ;
JNKK2 ;
MEK7 ;
MKK7 ;
PRKMK7 ;
SKK4 ;
Dual specificity mitogen-activated protein kinase kinase 7 ;
MAP kinase kinase 7 ;
MAPKK 7 ;
JNK-activating kinase 2 ;
MAPK/ERK kinase 7 ;
MEK 7 ;
Stress-activated protein kinase kinase 4 ;
SAPK kinase 4 ;
S

The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase specifically activates MAPK8/JNK1 and MAPK9/JNK2, and this kinase itself is phosphorylated and activated by MAP kinase kinase kinases including MAP3K1/MEKK1, MAP3K2/MEKK2,MAP3K3/MEKK5, and MAP4K2/GCK. This kinase is involved in the signal transduction mediating the cell responses to proinflammatory cytokines, and environmental stresses. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014],

Catalytic activity:ATP + a protein = ADP + a phosphoprotein.,cofactor:Magnesium.,enzyme regulation:Activated by phosphorylation by specific MAP kinase kinase kinases such as MAP3K1/MEKK1, MAP3K3/MEKK3, MAP3K11/MLK3 and MAP3K12/DLK.,Function:Stress activated, dual specificity kinase that activates the JUN kinases MAPK8/JNK1, MAPK9/JNK2 and MAPK10/JNK3.,PTM:Activated by phosphorylation on Ser/Thr.,similarity:Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.,similarity:Contains 1 protein kinase domain.,tissue specificity:Ubiquitous; with highest level of expression in skeletal muscle. Isoform 3 is found at low levels in placenta, fetal liver, and skeletal muscle.,

Nucleus. Cytoplasm .

>>MAPK signaling pathway ;
>>ErbB signaling pathway ;
>>Protein processing in endoplasmic reticulum ;
>>Osteoclast differentiation ;
>>Tight junction ;
>>Toll-like receptor signaling pathway ;
>>T cell receptor signaling pathway ;
>>Fc epsilon RI signaling pathway ;
>>TNF signaling pathway ;
>>Neurotrophin signaling pathway ;
>>GnRH signaling pathway ;
>>Relaxin signaling pathway ;
>>Alcoholic liver disease ;
>>Alzheimer disease ;
>>Huntington disease ;
>>Pathways of neurodegeneration - multiple diseases ;
>>Salmonella infection ;
>>Yersinia infection ;
>>Hepatitis B ;
>>Kaposi sarcoma-associated herpesvirus infection ;
>>Epstein-Barr virus infection ;
>>Human immunodeficiency virus 1 infection ;
>>Chemical carcinogenesis - reactive oxygen species ;
>>Lipid and atherosclerosis ;
>>Fluid shear stress and atherosclerosis