RPS6 (Phospho Ser240/Ser244) (PT0447R) PT™ Rabbit mAb
-YM8230
主要信息
Target
Ribosomal Protein S6 Phospho Ser240/244
Host Species
Rabbit
Reactivity
Human, Mouse, Rat
Applications
WB, IHC, IF, IP, ELISA
MW
29kD (Calculated)
32kD (Observed)
Conjugate/Modification
phosphate
货号: YM8230
规格
价格
货期
数量
200μL
￥3,580.00
现货
0
100μL
￥1,960.00
现货
0
40μL
￥960.00
现货
0
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详细信息
推荐稀释比
IHC 1:1000-1:4000; WB 1:2000-1:10000; IF 1:200-1:1000; ELISA 1:5000-1:20000; IP 1:50-1:200
组成
PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
特异性
This antibody detects endogenous levels of Ribosomal Protein S6 only when phosphorylated at Ser240 or Ser244.
纯化工艺
Recombinant Antibody expressed in animal component-free (ACF) media, purified via Protein A affinity chromatography.
储存
-15°C to -25°C/1 year (Do not lower than -25°C)
理论分子量
29kD
实测条带
32kD
修饰
phosphate
克隆性
Monoclonal
克隆号
PT0447R
同种型
IgG, Kappa
抗原&靶点信息
免疫原:
The specific immunogen used to produce this antibody is proprietary information.
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特异性:
This antibody detects endogenous levels of Ribosomal Protein S6 only when phosphorylated at Ser240 or Ser244.
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基因名称:
RPS6
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蛋白名称:
40S ribosomal protein S6
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别名:
RPS6 ;
OK/SW-cl.2 ;
40S ribosomal protein S6 ;
Phosphoprotein NP33
OK/SW-cl.2 ;
40S ribosomal protein S6 ;
Phosphoprotein NP33
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背景:
Ribosomes , the organelles that catalyze protein synthesis , consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a cytoplasmic ribosomal protein that is a component of the 40S subunit. The protein belongs to the S6E family of ribosomal proteins. It is the major substrate of protein kinases in the ribosome , with subsets of five C-terminal serine residues phosphorylated by different protein kinases. Phosphorylation is induced by a wide range of stimuli , including growth factors , tumor-promoting agents , and mitogens. Dephosphorylation occurs at growth arrest. The protein may contribute to the control of cell growth and proliferation through the selective translation of particular classes of mRNA. As is typical for genes encoding ribosomal proteins , there are multiple processed
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功能:
Function:May play an important role in controlling cell growth and proliferation through the selective translation of particular classes of mRNA. ,PTM:Ribosomal protein S6 is the major substrate of protein kinases in eukaryote ribosomes. The phosphorylation is stimulated by growth factors , tumor promoting agents , and mitogens. It is dephosphorylated at growth arrest. ,similarity:Belongs to the ribosomal protein S6e family. ,
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细胞定位:
nucleus ,nucleoplasm ,nucleolus ,cytoplasm ,cytosol ,ribosome ,polysome ,small ribosomal subunit ,membrane ,cytosolic small ribosomal subunit ,dendrite ,intracellular ribonucleoprotein complex ,cytoplasmic ribonucleoprotein granula
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组织表达:
研究领域:
>>EGFR tyrosine kinase inhibitor resistance ;
>>Ribosome ;
>>HIF-1 signaling pathway ;
>>mTOR signaling pathway ;
>>PI3K-Akt signaling pathway ;
>>Apelin signaling pathway ;
>>Thermogenesis ;
>>Insulin signaling pathway ;
>>Coronavirus disease - COVID-19 ;
>>Proteoglycans in cancer
>>Ribosome ;
>>HIF-1 signaling pathway ;
>>mTOR signaling pathway ;
>>PI3K-Akt signaling pathway ;
>>Apelin signaling pathway ;
>>Thermogenesis ;
>>Insulin signaling pathway ;
>>Coronavirus disease - COVID-19 ;
>>Proteoglycans in cancer
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信号通路
Organismal Systems >> Endocrine system >> Insulin signaling pathway
Environmental Information Processing >> Signal transduction >> Apelin signaling pathway
Environmental Information Processing >> Signal transduction >> HIF-1 signaling pathway
Environmental Information Processing >> Signal transduction >> PI3K-Akt signaling pathway
Environmental Information Processing >> Signal transduction >> mTOR signaling pathway
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货号: YM8230
规格
价格
货期
数量
200μL
￥3,580.00
现货
0
100μL
￥1,960.00
现货
0
40μL
￥960.00
现货
0
加入购物车
已收藏
收藏
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