The antiserum was produced against synthesized peptide derived from human p38 MAPK around the phosphorylation site of Thr180. AA range:147-196

Phospho-p38 (T180) Polyclonal Antibody detects endogenous levels of p38 protein only when phosphorylated at T180.The name of modified sites may be influenced by many factors, such as species (the modified site was not originally found in human samples) and the change of protein sequence (the previous protein sequence is incomplete, and the protein sequence may be prolonged with the development of protein sequencing technology). When naming, we will use the "numbers" in historical reference to keep the sites consistent with the reports. The antibody binds to the following modification sequence (lowercase letters are modification sites):EMtGY

MAPK14

Mitogen-activated protein kinase 14

MAPK14 ;
CSBP ;
CSBP1 ;
CSBP2 ;
CSPB1 ;
MXI2 ;
SAPK2A ;
Mitogen-activated protein kinase 14 ;
MAP kinase 14 ;
MAPK 14 ;
Cytokine suppressive anti-inflammatory drug-binding protein ;
CSAID-binding protein ;
CSBP ;
MAP kinase MXI2 ;
MAX-interacting protein

The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals , and are involved in a wide variety of cellular processes such as proliferation , differentiation , transcription regulation and development. This kinase is activated by various environmental stresses and proinflammatory cytokines. The activation requires its phosphorylation by MAP kinase kinases (MKKs) , or its autophosphorylation triggered by the interaction of MAP3K7IP1/TAB1 protein with this kinase. The substrates of this kinase include transcription regulator ATF2 , MEF2C , and MAX , cell cycle regulator CDC25B , and tumor suppressor p53 , which suggest the roles of this kinase in stress related transcription and cell cycle regulation , as well as in genotoxic stress response. Four alternatively spliced transcript variants of this gene encoding d

Catalytic activity:ATP + a protein = ADP + a phosphoprotein. ,cofactor:Magnesium. ,Domain:The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases. ,enzyme regulation:Activated by threonine and tyrosine phosphorylation by either of two dual specificity kinases , MAP2K3 or MAP2K6 , and potentially also MAP2K4. Inhibited by dual specificity phosphatases , such as DUSP1. Specifically inhibited by the binding of pyridinyl-imidazole compounds , which are cytokine-suppressive anti-inflammatory drugs (CSAID) . Isoform Mxi2 is 100-fold less sensitive to these agents than the other isoforms and is not inhibited by DUSP1. Isoform Exip is not activated by MAP2K6. ,Function:Responds to activation by environmental stress , pro-inflammatory cytokines and lipopolysaccharide (LPS) by phosphorylating a number of transcription factors , such as ELK1 and ATF2 and several downstream kinases , such as MAPKAPK2 and MAPKAPK5. Plays a critical role in the production of some cytokines , for example IL-6. May play a role in stabilization of EPO mRNA during hypoxic stress. Isoform Mxi2 activation is stimulated by mitogens and oxidative stress and only poorly phosphorylates ELK1 and ATF2. Isoform Exip may play a role in the early onset of apoptosis. ,online information:P38 mitogen-activated protein kinases entry ,PTM:Dually phosphorylated on Thr-180 and Tyr-182 , which activates the enzyme. ,PTM:Phosphorylated upon DNA damage , probably by ATM or ATR. ,similarity:Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily. ,similarity:Contains 1 protein kinase domain. ,subunit:Binds to a kinase interaction motif within the protein tyrosine phosphatase , PTPRR. This interaction retains MAPK14 in the cytoplasm and prevents nuclear accumulation. Interacts with SPAG9 (By similarity) . Interacts with NP60 and FAM48A. ,tissue specificity:Brain , heart , placenta , pancreas and skeletal muscle. Expressed to a lesser extent in lung , liver and kidney. ,

Cytoplasm . Nucleus .

>>Endocrine resistance ;
>>MAPK signaling pathway ;
>>Rap1 signaling pathway ;
>>FoxO signaling pathway ;
>>Sphingolipid signaling pathway ;
>>Oocyte meiosis ;
>>Cellular senescence ;
>>Adrenergic signaling in cardiomyocytes ;
>>VEGF signaling pathway ;
>>Osteoclast differentiation ;
>>Signaling pathways regulating pluripotency of stem cells ;
>>Platelet activation ;
>>Neutrophil extracellular trap formation ;
>>Toll-like receptor signaling pathway ;
>>NOD-like receptor signaling pathway ;
>>RIG-I-like receptor signaling pathway ;
>>C-type lectin receptor signaling pathway ;
>>IL-17 signaling pathway ;
>>Th1 and Th2 cell differentiation ;
>>Th17 cell differentiation ;
>>T cell receptor signaling pathway ;
>>Fc epsilon RI signaling pathway ;
>>TNF signaling pathway ;
>>Leukocyte transendothelial migration ;
>>Thermogenesis ;
>>Neurotrophin signaling pathway ;
>>Retrograde endocannabinoid signaling ;
>>Dopaminergic synapse ;
>>Inflammatory mediator regulation of TRP channels ;
>>GnRH signaling pathway ;
>>Progesterone-mediated oocyte maturation ;
>>Prolactin signaling pathway ;
>>Relaxin signaling pathway ;
>>Non-alcoholic fatty liver disease ;
>>AGE-RAGE signaling pathway in diabetic complications ;
>>Growth hormone synthesis , secretion and action ;
>>Alcoholic liver disease ;
>>Amyotrophic lateral sclerosis ;
>>Prion disease ;
>>Pathways of neurodegeneration - multiple diseases ;
>>Epithelial cell signaling in Helicobacter pylori infection ;
>>Pathogenic Escherichia coli infection ;
>>Shigellosis ;
>>Salmonella infection ;
>>Pertussis ;
>>Yersinia infection ;
>>Leishmaniasis ;
>>Chagas disease ;
>>Toxoplasmosis ;
>>Tuberculosis ;
>>Hepatitis B ;
>>Human cytomegalovirus infection ;
>>Kaposi sarcoma-associated herpesvirus infection ;
>>Epstein-Barr virus infection ;
>>Human immunodeficiency virus 1 infection ;
>>Coronavirus disease - COVID-19 ;
>>Proteoglycans in cancer ;
>>Chemical carcinogenesis - reactive oxygen species ;
>>PD-L1 expression and PD-1 checkpoint pathway in cancer ;
>>Diabetic cardiomyopathy ;
>>Lipid and atherosclerosis ;
>>Fluid shear stress and atherosclerosis