C3G (Phospho Tyr504) Rabbit pAb
-YP0377
主要信息
Target
C3G Phospho Tyr504
Host Species
Rabbit
Reactivity
Human
Applications
WB, IHC, IF, ELISA
MW
120kD (Observed)
Conjugate/Modification
Phospho
货号: YP0377
规格
价格
货期
数量
200μL
￥4,680.00
现货
0
100μL
￥2,800.00
现货
0
50μL
￥1,500.00
现货
0
加入购物车
已收藏
收藏
详细信息
推荐稀释比
WB 1:500-1:2000; ELISA 1:10000; IF 1:50-200
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
特异性
Phospho-C3G (Y504) Polyclonal Antibody detects endogenous levels of C3G protein only when phosphorylated at Y504.The name of modified sites may be influenced by many factors, such as species (the modified site was not originally found in human samples) and the change of protein sequence (the previous protein sequence is incomplete, and the protein sequence may be prolonged with the development of protein sequencing technology). When naming, we will use the "numbers" in historical reference to keep the sites consistent with the reports. The antibody binds to the following modification sequence (lowercase letters are modification sites):VPyAP
纯化工艺
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
浓度
1 mg/ml
实测条带
120kD
修饰
Phospho
克隆性
Polyclonal
同种型
IgG
相关产品
Secondary Antibodies
Goat Anti Mouse IgG(H+L) (HRP)
RS0001
预览→
Secondary Antibodies
Goat Anti Rabbit IgG(H+L) (HRP)
RS0002
预览→
Primary Antibodies
β-actin (PTR2364) Mouse mAb
YM3028
预览→
Primary Antibodies
GAPDH (PTR2304) Mouse mAb
YM3029
预览→
抗原&靶点信息
免疫原:
The antiserum was produced against synthesized peptide derived from human RapGEF1 around the phosphorylation site of Tyr504. AA range:470-519
展开内容
特异性:
Phospho-C3G (Y504) Polyclonal Antibody detects endogenous levels of C3G protein only when phosphorylated at Y504.The name of modified sites may be influenced by many factors, such as species (the modified site was not originally found in human samples) and the change of protein sequence (the previous protein sequence is incomplete, and the protein sequence may be prolonged with the development of protein sequencing technology). When naming, we will use the "numbers" in historical reference to keep the sites consistent with the reports. The antibody binds to the following modification sequence (lowercase letters are modification sites):VPyAP
展开内容
基因名称:
RAPGEF1
展开内容
蛋白名称:
Rap guanine nucleotide exchange factor 1
展开内容
别名:
RAPGEF1 ;
GRF2 ;
Rap guanine nucleotide exchange factor 1 ;
CRK SH3-binding GNRP ;
Guanine nucleotide-releasing factor 2 ;
Protein C3G
GRF2 ;
Rap guanine nucleotide exchange factor 1 ;
CRK SH3-binding GNRP ;
Guanine nucleotide-releasing factor 2 ;
Protein C3G
展开内容
背景:
This gene encodes a human guanine nucleotide exchange factor. It transduces signals from CRK by binding the SH3 domain of CRK, and activating several members of the Ras family of GTPases. This signaling cascade that may be involved in apoptosis, integrin-mediated signal transduction, and cell transformation. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some variants has not been determined. [provided by RefSeq, Jul 2008],
展开内容
功能:
Function:Guanine nucleotide-releasing protein that binds to SH3 domain of CRK and GRB2/ASH. Transduces signals from CRK to activate RAS.,similarity:Contains 1 N-terminal Ras-GEF domain.,similarity:Contains 1 Ras-GEF domain.,subunit:Interacts with CRK via its SH3-binding sites.,tissue specificity:Ubiquitously expressed in adult and fetus. Expression is high in adult skeletal muscle and placenta and in fetal brain and heart. Low levels of expression in adult and fetal liver.,
展开内容
细胞定位:
Early endosome .
展开内容
研究领域:
>>Rap1 signaling pathway ;
>>Focal adhesion ;
>>Neurotrophin signaling pathway ;
>>Insulin signaling pathway ;
>>Renal cell carcinoma
>>Focal adhesion ;
>>Neurotrophin signaling pathway ;
>>Insulin signaling pathway ;
>>Renal cell carcinoma
展开内容
信号通路
Cellular Processes >> Cellular community - eukaryotes >> Focal adhesion
Organismal Systems >> Endocrine system >> Insulin signaling pathway
Organismal Systems >> Nervous system >> Neurotrophin signaling pathway
Human Diseases >> Cancer: specific types >> Renal cell carcinoma
Environmental Information Processing >> Signal transduction >> Rap1 signaling pathway
文献引用（{{totalcount}}）
货号: YP0377
规格
价格
货期
数量
200μL
￥4,680.00
现货
0
100μL
￥2,800.00
现货
0
50μL
￥1,500.00
现货
0
加入购物车
已收藏
收藏
Recently Viewed Products
Clear all
×
Toggle night Mode
{{pinfoXq.title || ''}}
Catalog: {{pinfoXq.catalog || ''}}
Filter：
All
{{item.name}}
{{pinfo.title}}
-{{pinfo.catalog}}
主要信息
Target
{{pinfo.target}}
Reactivity
{{pinfo.react}}
Applications
{{pinfo.applicat}}
Conjugate/Modification
{{pinfo.coupling}}/{{pinfo.modific}}
MW (kDa)
{{pinfo.mwcalc}}
Host Species
{{pinfo.hostspec}}
Isotype
{{pinfo.isotype}}
产品 {{index}}/{{pcount}}
上一个产品
下一个产品
{{pvTitle}}
滚轮缩放图片
{{pvDescr}}