ULK1 (Phospho Ser556) (PT0907R) PT™ Rabbit mAb
-YM8654
主要信息
Target
ULK1 Phospho Ser556
Host Species
Rabbit
Reactivity
Human, Mouse, Rat
Applications
WB, IF, ELISA
MW
113kD (Calculated)
130kD (Observed)
Conjugate/Modification
phosphate
货号: YM8654
规格
价格
货期
数量
200μL
￥3,580.00
现货
0
100μL
￥1,960.00
现货
0
40μL
￥960.00
现货
0
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详细信息
推荐稀释比
WB 1:2000-1:10000; IF 1:200-1:1000; ELISA 1:5000-1:20000
组成
PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
特异性
ULK1 (Phospho Ser556) Monoclonal Antibody detects endogenous levels of ULK1 around the phosphorylation site of S556 protein.The name of modified sites may be influenced by many factors, such as species (the modified site was not originally found in human samples) and the change of protein sequence (the previous protein sequence is incomplete, and the protein sequence may be prolonged with the development of protein sequencing technology). When naming, we will use the "numbers" in historical reference to keep the sites consistent with the reports. The antibody binds to the following modification sequence (lowercase letters are modification sites):LHsAP
纯化工艺
Recombinant Antibody expressed in animal component-free (ACF) media, purified via Protein A affinity chromatography.
储存
-15°C to -25°C/1 year (Do not lower than -25°C)
理论分子量
113kD
实测条带
130kD
修饰
phosphate
克隆性
Monoclonal
克隆号
PT0907R
同种型
IgG, Kappa
RRID号
AB_3712221
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抗原&靶点信息
免疫原:
The specific immunogen used to produce this antibody is proprietary information.
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种属预测:
以下所列种属仅供参考。建议仅在目标物种与免疫原序列同源性高于80%时尝试用于WB等实验。由于蛋白表达存在种属、组织或细胞差异，即使同源性较高，实际效果仍需实验验证。本预测基于序列比对，结果仅供参考，不作为质保依据。
Homolo ≥ 90%
80% ≤ Homolo < 90%
0% < Homolo < 80%
特异性:
ULK1 (Phospho Ser556) Monoclonal Antibody detects endogenous levels of ULK1 around the phosphorylation site of S556 protein.The name of modified sites may be influenced by many factors, such as species (the modified site was not originally found in human samples) and the change of protein sequence (the previous protein sequence is incomplete, and the protein sequence may be prolonged with the development of protein sequencing technology). When naming, we will use the "numbers" in historical reference to keep the sites consistent with the reports. The antibody binds to the following modification sequence (lowercase letters are modification sites):LHsAP
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基因名称:
ULK1 KIAA0722
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蛋白名称:
ULK1 (Ser556)
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别名:
Serine/threonine-protein kinase ULK1 ;
Autophagy-related protein 1 homolog ;
ATG1 ;
hATG1 ;
Unc-51-like kinase 1 ;
Autophagy-related protein 1 homolog ;
ATG1 ;
hATG1 ;
Unc-51-like kinase 1 ;
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背景:
catalytic activity:ATP + a protein = ADP + a phosphoprotein. ,function:Involved in axon growth. Plays an essential role in neurite extension of cerebellar granule cells. ,similarity:Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. APG1/unc-51/ULK1 subfamily. ,similarity:Contains 1 protein kinase domain. ,subunit:Interacts with GABARAP and GABARAPL2. ,tissue specificity:Ubiquitously expressed. Detected in the following adult tissues: skeletal muscle , heart , pancreas , brain , placenta , liver , kidney , and lung. ,
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功能:
Catalytic activity:ATP + a protein = ADP + a phosphoprotein. ,Function:Involved in axon growth. Plays an essential role in neurite extension of cerebellar granule cells. ,similarity:Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. APG1/unc-51/ULK1 subfamily. ,similarity:Contains 1 protein kinase domain. ,subunit:Interacts with GABARAP and GABARAPL2. ,tissue specificity:Ubiquitously expressed. Detected in the following adult tissues: skeletal muscle , heart , pancreas , brain , placenta , liver , kidney , and lung. ,
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细胞定位:
Cytoplasm , cytosol . Preautophagosomal structure . Under starvation conditions , is localized to puncate structures primarily representing the isolation membrane that sequesters a portion of the cytoplasm resulting in the formation of an autophagosome. .
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研究领域:
>>Mitophagy - animal ;
>>Autophagy - animal ;
>>mTOR signaling pathway ;
>>AMPK signaling pathway ;
>>Longevity regulating pathway ;
>>Alzheimer disease ;
>>Amyotrophic lateral sclerosis ;
>>Huntington disease ;
>>Spinocerebellar ataxia ;
>>Pathways of neurodegeneration - multiple diseases
>>Autophagy - animal ;
>>mTOR signaling pathway ;
>>AMPK signaling pathway ;
>>Longevity regulating pathway ;
>>Alzheimer disease ;
>>Amyotrophic lateral sclerosis ;
>>Huntington disease ;
>>Spinocerebellar ataxia ;
>>Pathways of neurodegeneration - multiple diseases
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信号通路
Cellular Processes >> Transport and catabolism >> Autophagy - animal
Cellular Processes >> Transport and catabolism >> Mitophagy - animal
Organismal Systems >> Aging >> Longevity regulating pathway
Human Diseases >> Neurodegenerative disease >> Alzheimer disease
Human Diseases >> Neurodegenerative disease >> Amyotrophic lateral sclerosis
Human Diseases >> Neurodegenerative disease >> Huntington disease
Human Diseases >> Neurodegenerative disease >> Spinocerebellar ataxia
Human Diseases >> Neurodegenerative disease >> Pathways of neurodegeneration - multiple diseases
Environmental Information Processing >> Signal transduction >> AMPK signaling pathway
Environmental Information Processing >> Signal transduction >> mTOR signaling pathway
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货号: YM8654
规格
价格
货期
数量
200μL
￥3,580.00
现货
0
100μL
￥1,960.00
现货
0
40μL
￥960.00
现货
0
加入购物车
已收藏
收藏
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