Acetyl-CoA Carboxylase (Phospho Ser79) (PT0983R) PT™ Rabbit mAb
-YM8749
主要信息
Target
ACC Phospho Ser79
Host Species
Rabbit
Reactivity
Human, Mouse, Rat
Applications
WB, IHC, IF, IP, ELISA
MW
266kD (Calculated)
266kD (Observed)
Conjugate/Modification
phosphate
货号: YM8749
规格
价格
货期
数量
200μL
￥3,580.00
现货
0
100μL
￥1,960.00
现货
0
40μL
￥960.00
现货
0
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详细信息
推荐稀释比
IHC 1:200-1:1000; WB 1:1000-1:15000; IF 1:200-1:1000; ELISA 1:5000-1:20000; IP 1:50-1:200
组成
PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
特异性
Acetyl-CoA Carboxylase (Phospho Ser79) Monoclonal Antibody detects endogenous levels of ACC protein only when phosphorylated at S79.The name of modified sites may be influenced by many factors, such as species (the modified site was not originally found in human samples) and the change of protein sequence (the previous protein sequence is incomplete, and the protein sequence may be prolonged with the development of protein sequencing technology). When naming, we will use the "numbers" in historical reference to keep the sites consistent with the reports. The antibody binds to the following modification sequence (lowercase letters are modification sites):SSmSG
纯化工艺
Recombinant Antibody expressed in animal component-free (ACF) media, purified via Protein A affinity chromatography.
储存
-15°C to -25°C/1 year (Do not lower than -25°C)
理论分子量
266kD
实测条带
266kD
修饰
phosphate
克隆性
Monoclonal
克隆号
PT0983R
同种型
IgG, Kappa
RRID号
AB_3711770
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抗原&靶点信息
免疫原:
The specific immunogen used to produce this antibody is proprietary information.
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种属预测:
以下所列种属仅供参考。建议仅在目标物种与免疫原序列同源性高于80%时尝试用于WB等实验。由于蛋白表达存在种属、组织或细胞差异，即使同源性较高，实际效果仍需实验验证。本预测基于序列比对，结果仅供参考，不作为质保依据。
Homolo ≥ 90%
80% ≤ Homolo < 90%
0% < Homolo < 80%
特异性:
Acetyl-CoA Carboxylase (Phospho Ser79) Monoclonal Antibody detects endogenous levels of ACC protein only when phosphorylated at S79.The name of modified sites may be influenced by many factors, such as species (the modified site was not originally found in human samples) and the change of protein sequence (the previous protein sequence is incomplete, and the protein sequence may be prolonged with the development of protein sequencing technology). When naming, we will use the "numbers" in historical reference to keep the sites consistent with the reports. The antibody binds to the following modification sequence (lowercase letters are modification sites):SSmSG
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基因名称:
ACACB;ACACA
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蛋白名称:
ACC,Acetyl-CoA carboxylase 2;ACC-beta;Acetyl-CoA carboxylase 1;ACC1;
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别名:
ACACA ;
ACAC ;
ACC1 ;
ACCA ;
Acetyl-CoA carboxylase 1 ;
ACC1 ;
ACC-alpha ;
ACACB,Acetyl CoA carboxylase 2,ACC beta,ACC2,ACCB,AcetylCoA carboxylase 2,ACCbeta,ACCβ,ACC β,
ACAC ;
ACC1 ;
ACCA ;
Acetyl-CoA carboxylase 1 ;
ACC1 ;
ACC-alpha ;
ACACB,Acetyl CoA carboxylase 2,ACC beta,ACC2,ACCB,AcetylCoA carboxylase 2,ACCbeta,ACCβ,ACC β,
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数据库链接:
背景:
Acetyl-CoA carboxylase (ACC) is a complex multifunctional enzyme system. ACC is a biotin-containing enzyme which catalyzes the carboxylation of acetyl-CoA to malonyl-CoA , the rate-limiting step in fatty acid synthesis. ACC-beta is thought to control fatty acid oxidation by means of the ability of malonyl-CoA to inhibit carnitine-palmitoyl-CoA transferase I , the rate-limiting step in fatty acid uptake and oxidation by mitochondria. ACC-beta may be involved in the regulation of fatty acid oxidation , rather than fatty acid biosynthesis. There is evidence for the presence of two ACC-beta isoforms. [provided by RefSeq , Jul 2008] ,
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功能:
Catalytic activity:ATP + acetyl-CoA + HCO (3) (-) = ADP + phosphate + malonyl-CoA. ,Catalytic activity:ATP + biotin-carboxyl-carrier protein + CO (2) = ADP + phosphate + carboxybiotin-carboxyl-carrier protein. ,cofactor:Binds 2 manganese ions per subunit. ,cofactor:Biotin. ,enzyme regulation:Activated by citrate. Inhibited by malonyl-CoA. ,Function:ACC-beta may be involved in the provision of malonyl-CoA or in the regulation of fatty acid oxidation , rather than fatty acid biosynthesis. Carries out three functions: biotin carboxyl carrier protein , biotin carboxylase and carboxyltransferase. ,pathway:Lipid metabolism; malonyl-CoA biosynthesis; malonyl-CoA from acetyl-CoA: step 1/1. ,similarity:Contains 1 ATP-grasp domain. ,similarity:Contains 1 biotin carboxylation domain. ,similarity:Contains 1 biotinyl-binding domain. ,similarity:Contains 1 carboxyltransferase domain. ,subcellular location:May associate with membranes. ,tissue specificity:Predominantly expressed in the heart , skeletal muscles and liver. ,
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细胞定位:
Mitochondrion
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研究领域:
>>Fatty acid biosynthesis ;
>>Pyruvate metabolism ;
>>Propanoate metabolism ;
>>Metabolic pathways ;
>>AMPK signaling pathway ;
>>Insulin signaling pathway ;
>>Adipocytokine signaling pathway ;
>>Glucagon signaling pathway ;
>>Insulin resistance ;
>>Alcoholic liver disease
>>Pyruvate metabolism ;
>>Propanoate metabolism ;
>>Metabolic pathways ;
>>AMPK signaling pathway ;
>>Insulin signaling pathway ;
>>Adipocytokine signaling pathway ;
>>Glucagon signaling pathway ;
>>Insulin resistance ;
>>Alcoholic liver disease
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信号通路
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货号: YM8749
规格
价格
货期
数量
200μL
￥3,580.00
现货
0
100μL
￥1,960.00
现货
0
40μL
￥960.00
现货
0
加入购物车
已收藏
收藏
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