MLKL (Phospho Ser345) (PT0987R) PT™ Rabbit mAb
-YM8687
主要信息
Target
MLKL Phospho Ser345
Host Species
Rabbit
Reactivity
Mouse
Applications
WB, IF, ELISA
MW
54kD (Calculated)
54kD (Observed)
Conjugate/Modification
phosphate
货号: YM8687
规格
价格
货期
数量
200μL
￥3,580.00
现货
0
100μL
￥1,960.00
现货
0
40μL
￥960.00
现货
0
加入购物车
已收藏
收藏
详细信息
推荐稀释比
WB 1:2000-1:10000; IF 1:200-1:1000; ELISA 1:5000-1:20000
组成
PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
特异性
MLKL (Phospho Ser345) Monoclonal Antibody detects endogenous levels of MLKL Phospho-ser345 at Human, Mouse,Rat.The name of modified sites may be influenced by many factors, such as species (the modified site was not originally found in human samples) and the change of protein sequence (the previous protein sequence is incomplete, and the protein sequence may be prolonged with the development of protein sequencing technology). When naming, we will use the "numbers" in historical reference to keep the sites consistent with the reports. The antibody binds to the following modification sequence (lowercase letters are modification sites):QNsIS
纯化工艺
Recombinant Antibody expressed in animal component-free (ACF) media, purified via Protein A affinity chromatography.
储存
-15°C to -25°C/1 year (Do not lower than -25°C)
理论分子量
54kD
实测条带
54kD
修饰
phosphate
克隆性
Monoclonal
克隆号
PT0987R
同种型
IgG, Kappa
RRID号
AB_3699185
相关产品
Secondary Antibodies
Goat Anti Mouse IgG(H+L) (HRP)
RS0001
预览→
Secondary Antibodies
Goat Anti Rabbit IgG(H+L) (HRP)
RS0002
预览→
Primary Antibodies
β-actin (PTR2364) Mouse mAb
YM3028
预览→
Primary Antibodies
ERCC1 (1B10) Mouse mAb
YM3078
预览→
抗原&靶点信息
免疫原:
The specific immunogen used to produce this antibody is proprietary information.
展开内容
特异性:
MLKL (Phospho Ser345) Monoclonal Antibody detects endogenous levels of MLKL Phospho-ser345 at Human, Mouse,Rat.The name of modified sites may be influenced by many factors, such as species (the modified site was not originally found in human samples) and the change of protein sequence (the previous protein sequence is incomplete, and the protein sequence may be prolonged with the development of protein sequencing technology). When naming, we will use the "numbers" in historical reference to keep the sites consistent with the reports. The antibody binds to the following modification sequence (lowercase letters are modification sites):QNsIS
展开内容
基因名称:
MLKL
展开内容
蛋白名称:
MLKL Phospho-ser345
展开内容
别名:
Mixed lineage kinase domain-like protein
展开内容
背景:
This gene belongs to the protein kinase superfamily. The encoded protein contains a protein kinase-like domain; however , is thought to be inactive because it lacks several residues required for activity. This protein plays a critical role in tumor necrosis factor (TNF) -induced necroptosis , a programmed cell death process , via interaction with receptor-interacting protein 3 (RIP3) , which is a key signaling molecule in necroptosis pathway. Inhibitor studies and knockdown of this gene inhibited TNF-induced necrosis. High levels of this protein and RIP3 are associated with inflammatory bowel disease in children. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq , Sep 2015] ,
展开内容
功能:
Domain:The protein kinase domain is predicted to be catalytically inactive. ,similarity:Belongs to the protein kinase superfamily. ,similarity:Contains 1 protein kinase domain. ,
展开内容
细胞定位:
Cytoplasm . Cell membrane . Nucleus . Localizes to the cytoplasm and translocates to the plasma membrane on necroptosis induction (PubMed:24316671) . Localizes to the nucleus in response to orthomyxoviruses infection (By similarity) . .
展开内容
组织表达:
研究领域:
>>Necroptosis ;
>>TNF signaling pathway ;
>>Salmonella infection
>>TNF signaling pathway ;
>>Salmonella infection
展开内容
信号通路
文献引用（{{totalcount}}）
货号: YM8687
规格
价格
货期
数量
200μL
￥3,580.00
现货
0
100μL
￥1,960.00
现货
0
40μL
￥960.00
现货
0
加入购物车
已收藏
收藏
Recently Viewed Products
Clear all
×
Toggle night Mode
{{pinfoXq.title || ''}}
Catalog: {{pinfoXq.catalog || ''}}
Filter：
All
{{item.name}}
{{pinfo.title}}
-{{pinfo.catalog}}
主要信息
Target
{{pinfo.target}}
Reactivity
{{pinfo.react}}
Applications
{{pinfo.applicat}}
Conjugate/Modification
{{pinfo.coupling}}/{{pinfo.modific}}
MW (kDa)
{{pinfo.mwcalc}}
Host Species
{{pinfo.hostspec}}
Isotype
{{pinfo.isotype}}
产品 {{index}}/{{pcount}}
上一个产品
下一个产品
{{pvTitle}}
滚轮缩放图片
{{pvDescr}}