c-Myb (Phospho Ser11) (PT1200R) PT™ Rabbit mAb
-YM9042
主要信息
Target
c-Myb Phospho Ser11
Host Species
Rabbit
Reactivity
Human, Mouse, Rat
Applications
WB, IHC, IF, IP, ELISA
MW
72kD (Calculated)
80kD (Observed)
Conjugate/Modification
phosphate
货号: YM9042
规格
价格
货期
数量
200μL
￥3,580.00
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0
100μL
￥1,960.00
现货
0
40μL
￥960.00
现货
0
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详细信息
推荐稀释比
IHC 1:200-1:1000; WB 1:2000-1:10000; IF 1:200-1:1000; ELISA 1:5000-1:20000; IP 1:50-1:200
组成
PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
特异性
c-Myb (Phospho Ser11) Antibody detects endogenous levels of c-Myb protein only when phosphorylated at S11.The name of modified sites may be influenced by many factors, such as species (the modified site was not originally found in human samples) and the change of protein sequence (the previous protein sequence is incomplete, and the protein sequence may be prolonged with the development of protein sequencing technology). When naming, we will use the "numbers" in historical reference to keep the sites consistent with the reports. The antibody binds to the following modification sequence (lowercase letters are modification sites):IYsSD
纯化工艺
Recombinant Antibody expressed in animal component-free (ACF) media, purified via Protein A affinity chromatography.
储存
-15°C to -25°C/1 year (Do not lower than -25°C)
理论分子量
72kD
实测条带
80kD
修饰
phosphate
克隆性
Monoclonal
克隆号
PT1200R
同种型
IgG, Kappa
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抗原&靶点信息
免疫原:
The specific immunogen used to produce this antibody is proprietary information.
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种属预测:
以下所列种属仅供参考。建议仅在目标物种与免疫原序列同源性高于80%时尝试用于WB等实验。由于蛋白表达存在种属、组织或细胞差异，即使同源性较高，实际效果仍需实验验证。本预测基于序列比对，结果仅供参考，不作为质保依据。
Homolo ≥ 90%
80% ≤ Homolo < 90%
0% < Homolo < 80%
特异性:
c-Myb (Phospho Ser11) Antibody detects endogenous levels of c-Myb protein only when phosphorylated at S11.The name of modified sites may be influenced by many factors, such as species (the modified site was not originally found in human samples) and the change of protein sequence (the previous protein sequence is incomplete, and the protein sequence may be prolonged with the development of protein sequencing technology). When naming, we will use the "numbers" in historical reference to keep the sites consistent with the reports. The antibody binds to the following modification sequence (lowercase letters are modification sites):IYsSD
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基因名称:
MYB
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蛋白名称:
Transcriptional activator Myb
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别名:
MYB ;
Transcriptional activator Myb ;
Proto-oncogene c-Myb
Transcriptional activator Myb ;
Proto-oncogene c-Myb
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背景:
This gene encodes a protein with three HTH DNA-binding domains that functions as a transcription regulator. This protein plays an essential role in the regulation of hematopoiesis. This gene may be aberrently expressed or rearranged or undergo translocation in leukemias and lymphomas , and is considered to be an oncogene. Alternative splicing results in multiple transcript variants. [provided by RefSeq , Jan 2016] ,
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功能:
Domain:Comprised of 3 domains; an N-terminal DNA-binding domain , a centrally located transcriptional activation domain and a C-terminal domain involved in transcriptional repression. ,Function:Transcriptional activator; DNA-binding protein that specifically recognize the sequence 5'-YAAC[GT]G-3'. Plays an important role in the control of proliferation and differentiation of hematopoietic progenitor cells. ,PTM:Phosphorylated by NLK on multiple sites , which induces proteasomal degradation. ,PTM:Ubiquitinated; mediated by SIAH1 and leading to its subsequent proteasomal degradation. ,similarity:Contains 3 HTH myb-type DNA-binding domains. ,subunit:Binds MYBBP1A. Interacts with HIPK2 , MAF and NLK. ,
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细胞定位:
Nucleus .
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组织表达:
研究领域:
>>PI3K-Akt signaling pathway
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货号: YM9042
规格
价格
货期
数量
200μL
￥3,580.00
现货
0
100μL
￥1,960.00
现货
0
40μL
￥960.00
现货
0
加入购物车
已收藏
收藏
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