YAP (Phospho Ser397) (PT1357R) PT™ Rabbit mAb
-YM9199
主要信息
Target
YAP Phospho Ser397
Host Species
Rabbit
Reactivity
Human, Mouse, Rat
Applications
WB, IF, IP, ELISA
MW
54kD (Calculated)
65kD (Observed)
Conjugate/Modification
phosphate
货号: YM9199
规格
价格
货期
数量
200μL
￥3,580.00
现货
0
100μL
￥1,960.00
现货
0
40μL
￥960.00
现货
0
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详细信息
推荐稀释比
WB 1:2000-1:10000; IF 1:200-1:1000; ELISA 1:5000-1:20000; IP 1:50-1:200
组成
PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
特异性
YAP (Phospho Ser397) Antibody detects endogenous levels of YAP protein only when phosphorylated at Ser397.The name of modified sites may be influenced by many factors, such as species (the modified site was not originally found in human samples) and the change of protein sequence (the previous protein sequence is incomplete, and the protein sequence may be prolonged with the development of protein sequencing technology). When naming, we will use the "numbers" in historical reference to keep the sites consistent with the reports. The antibody binds to the following modification sequence (lowercase letters are modification sites):DEsTD
纯化工艺
Recombinant Antibody expressed in animal component-free (ACF) media, purified via Protein A affinity chromatography.
储存
-15°C to -25°C/1 year (Do not lower than -25°C)
理论分子量
54kD
实测条带
65kD
修饰
phosphate
克隆性
Monoclonal
克隆号
PT1357R
同种型
IgG, Kappa
相关产品
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ELISA Kits
Total YAP Cell-Based Colorimetric ELISA Kit
KA3612C
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ELISA Kits
YAP (Phospho Ser127) Cell-Based Colorimetric ELISA Kit
KA1392C
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抗原&靶点信息
免疫原:
The specific immunogen used to produce this antibody is proprietary information.
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特异性:
YAP (Phospho Ser397) Antibody detects endogenous levels of YAP protein only when phosphorylated at Ser397.The name of modified sites may be influenced by many factors, such as species (the modified site was not originally found in human samples) and the change of protein sequence (the previous protein sequence is incomplete, and the protein sequence may be prolonged with the development of protein sequencing technology). When naming, we will use the "numbers" in historical reference to keep the sites consistent with the reports. The antibody binds to the following modification sequence (lowercase letters are modification sites):DEsTD
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基因名称:
YAP1 YAP65
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蛋白名称:
Transcriptional coactivator YAP1
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别名:
Yorkie homolog ;
65 kDa Yes-associated protein ;
YAP65 ;
65 kDa Yes-associated protein ;
YAP65 ;
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背景:
This gene encodes a downstream nuclear effector of the Hippo signaling pathway which is involved in development , growth , repair , and homeostasis. This gene is known to play a role in the development and progression of multiple cancers as a transcriptional regulator of this signaling pathway and may function as a potential target for cancer treatment. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq , Aug 2013] ,
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功能:
PTM:Phosphorylated upon DNA damage , probably by ATM or ATR. ,similarity:Contains 1 WW domain. ,subunit:Binds to the SH3 domain of the YES kinase. Binds to WBP1 and WBP2. Binds , in vitro , through the WW1 domain , to neural isoforms of ENAH that contain the PPSY motif. ,
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细胞定位:
Cytoplasm . Nucleus . Both phosphorylation and cell density can regulate its subcellular localization (PubMed:18158288 , PubMed:20048001) . Phosphorylation sequesters it in the cytoplasm by inhibiting its translocation into the nucleus (PubMed:18158288 , PubMed:20048001) . At low density , predominantly nuclear and is translocated to the cytoplasm at high density (PubMed:18158288 , PubMed:20048001 , PubMed:25849865) . PTPN14 induces translocation from the nucleus to the cytoplasm (PubMed:22525271) . Localized mainly to the nucleus in the early stages of embryo development with expression becoming evident in the cytoplasm at the blastocyst and epiblast stages (By similarity) . .
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研究领域:
>>Hippo signaling pathway ;
>>Hippo signaling pathway - multiple species
>>Hippo signaling pathway - multiple species
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信号通路
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货号: YM9199
规格
价格
货期
数量
200μL
￥3,580.00
现货
0
100μL
￥1,960.00
现货
0
40μL
￥960.00
现货
0
加入购物车
已收藏
收藏
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