TrkA (Phospho Tyr490) /TrkB (Phospho Tyr516) (PT1381R) PT™ Rabbit mAb
-YM9223
主要信息
Target
TrkA/TrkB Phospho Tyr490/Tyr516
Host Species
Rabbit
Reactivity
Human, Mouse, Rat
Applications
WB, IF, IP, ELISA
MW
92kD,87kD (Calculated)
92kD,87kD (Observed)
Conjugate/Modification
phosphate
货号: YM9223
规格
价格
货期
数量
200μL
￥3,580.00
现货
0
100μL
￥1,960.00
现货
0
40μL
￥960.00
现货
0
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详细信息
推荐稀释比
WB 1:2000-1:10000; IF 1:200-1:1000; ELISA 1:5000-1:20000; IP 1:50-1:200
组成
PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
特异性
TrkA (Phospho Tyr490)/TrkB (Phospho Tyr516) Antibody detects endogenous levels of TrkA/TrkB protein only when phosphorylated at Y490/Y516.The name of modified sites may be influenced by many factors, such as species (the modified site was not originally found in human samples) and the change of protein sequence (the previous protein sequence is incomplete, and the protein sequence may be prolonged with the development of protein sequencing technology). When naming, we will use the "numbers" in historical reference to keep the sites consistent with the reports. The antibody binds to the following modification sequence (lowercase letters are modification sites):GHiIE/PQyFG
纯化工艺
Recombinant Antibody expressed in animal component-free (ACF) media, purified via Protein A affinity chromatography.
储存
-15°C to -25°C/1 year (Do not lower than -25°C)
理论分子量
92kD,87kD
实测条带
92kD,87kD
修饰
phosphate
克隆性
Monoclonal
克隆号
PT1381R
同种型
IgG, Kappa
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抗原&靶点信息
免疫原:
The specific immunogen used to produce this antibody is proprietary information.
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特异性:
TrkA (Phospho Tyr490)/TrkB (Phospho Tyr516) Antibody detects endogenous levels of TrkA/TrkB protein only when phosphorylated at Y490/Y516.The name of modified sites may be influenced by many factors, such as species (the modified site was not originally found in human samples) and the change of protein sequence (the previous protein sequence is incomplete, and the protein sequence may be prolonged with the development of protein sequencing technology). When naming, we will use the "numbers" in historical reference to keep the sites consistent with the reports. The antibody binds to the following modification sequence (lowercase letters are modification sites):GHiIE/PQyFG
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基因名称:
NTRK1;MTC;TRK;TRKA;NTRK2;TRKB;
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蛋白名称:
High affinity nerve growth factor receptor;Neurotrophic tyrosine kinase receptor type 1;TRK1-transforming tyrosine kinase protein;Tropomyosin-related kinase A;Tyrosine kinase receptor;Tyrosine kinase receptor A;Trk-A;gp140trk;p140-TrkA;BDNF/NT-3 growth factors receptor;GP145-TrkB;Trk-B;Neurotrophic tyrosine kinase receptor type 2;TrkB tyrosine kinase;Tropomyosin-related kinase B;
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别名:
NTRK1 ;
MTC ;
TRK ;
TRKA ;
High affinity nerve growth factor receptor ;
Neurotrophic tyrosine kinase receptor type 1 ;
TRK1-transforming tyrosine kinase protein ;
Tropomyosin-related kinase A ;
Tyrosine kinase receptor ;
Tyrosine kinase receptor A ;
MTC ;
TRK ;
TRKA ;
High affinity nerve growth factor receptor ;
Neurotrophic tyrosine kinase receptor type 1 ;
TRK1-transforming tyrosine kinase protein ;
Tropomyosin-related kinase A ;
Tyrosine kinase receptor ;
Tyrosine kinase receptor A ;
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数据库链接:
背景:
This gene encodes a member of the neurotrophic tyrosine kinase receptor (NTKR) family. This kinase is a membrane-bound receptor that , upon neurotrophin binding , phosphorylates itself and members of the MAPK pathway. The presence of this kinase leads to cell differentiation and may play a role in specifying sensory neuron subtypes. Mutations in this gene have been associated with congenital insensitivity to pain , anhidrosis , self-mutilating behavior , mental retardation and cancer. Alternate transcriptional splice variants of this gene have been found , but only three have been characterized to date. [provided by RefSeq , Jul 2008] ,
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功能:
Family of neurotrophic tyrosine kinase (NTRK1/2/3) genes which encode TrkA , TrkB and TrkC protein kinases. The three family members are activated by different neurotrophins: TrkA is activated by Nerve growth factor (NGF) , TrkB by Brain-derived neurotrophic factor (BDNF) or neurotrophin-4 (NT-4) and TrkC by NT-3. Neurotrophin signalling activates cellular pathways involved in the development and the maturation of the central and peripheral nervous systems through regulation of proliferation , differentiation and survival of sympathetic and nervous neurons. Localization TrkA: Cell membrane. Early endosome membrane. Late endosome membrane. Internalized to endosomes upon binding of NGF or NT-3 and further transported to the cell body via a retrograde axonal transport. Localized at cell membrane and early endosomes before nerve growth factor (NGF) stimulation. Recruited to late endosomes after NGF stimulation. Colocalized with RAPGEF2 at late endosomes (By similarity) . TrkB: Membrane. TrkC: Membrane.
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细胞定位:
Membrane
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研究领域:
>>MAPK signaling pathway ;
>>Ras signaling pathway ;
>>Calcium signaling pathway ;
>>PI3K-Akt signaling pathway ;
>>Apoptosis ;
>>Neurotrophin signaling pathway ;
>>Inflammatory mediator regulation of TRP channels ;
>>Pathways in cancer ;
>>Transcriptional misregulation in cancer ;
>>Thyroid cancer ;
>>Central carbon metabolism in cancer
>>Ras signaling pathway ;
>>Calcium signaling pathway ;
>>PI3K-Akt signaling pathway ;
>>Apoptosis ;
>>Neurotrophin signaling pathway ;
>>Inflammatory mediator regulation of TRP channels ;
>>Pathways in cancer ;
>>Transcriptional misregulation in cancer ;
>>Thyroid cancer ;
>>Central carbon metabolism in cancer
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信号通路
Cellular Processes >> Cell growth and death >> Apoptosis
Organismal Systems >> Nervous system >> Neurotrophin signaling pathway
Organismal Systems >> Sensory system >> Inflammatory mediator regulation of TRP channels
Human Diseases >> Cancer: overview >> Pathways in cancer
Human Diseases >> Cancer: overview >> Transcriptional misregulation in cancer
Human Diseases >> Cancer: overview >> Central carbon metabolism in cancer
Human Diseases >> Cancer: specific types >> Thyroid cancer
Environmental Information Processing >> Signal transduction >> MAPK signaling pathway
Environmental Information Processing >> Signal transduction >> Ras signaling pathway
Environmental Information Processing >> Signal transduction >> Calcium signaling pathway
Environmental Information Processing >> Signal transduction >> PI3K-Akt signaling pathway
文献引用（{{totalcount}}）
货号: YM9223
规格
价格
货期
数量
200μL
￥3,580.00
现货
0
100μL
￥1,960.00
现货
0
40μL
￥960.00
现货
0
加入购物车
已收藏
收藏
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