NF-M (Phospho Ser614/Ser619) (PT1444R) PT™ Rabbit mAb
-YM9286
主要信息
Target
NF-M Phospho Ser614/Ser619
Host Species
Rabbit
Reactivity
Human, Mouse, Rat
Applications
WB, IHC, IF, ELISA
MW
103kD (Calculated)
180kD (Observed)
Conjugate/Modification
phosphate
货号: YM9286
规格
价格
货期
数量
200μL
￥3,580.00
现货
0
100μL
￥1,960.00
现货
0
40μL
￥960.00
现货
0
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详细信息
推荐稀释比
IHC 1:200-1:1000; WB 1:500-1:2000; IF 1:200-1:1000; ELISA 1:5000-1:20000
组成
PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
特异性
NF-M (Phospho Ser614/Ser619) Antibody detects endogenous levels of NF-M protein only when phosphorylated at S614/S619.The name of modified sites may be influenced by many factors, such as species (the modified site was not originally found in human samples) and the change of protein sequence (the previous protein sequence is incomplete, and the protein sequence may be prolonged with the development of protein sequencing technology). When naming, we will use the "numbers" in historical reference to keep the sites consistent with the reports. The antibody binds to the following modification sequence (lowercase letters are modification sites):KAkSP/VPkSP
纯化工艺
Recombinant Antibody expressed in animal component-free (ACF) media, purified via Protein A affinity chromatography.
储存
-15°C to -25°C/1 year (Do not lower than -25°C)
理论分子量
103kD
实测条带
180kD
修饰
phosphate
克隆性
Monoclonal
克隆号
PT1444R
同种型
IgG, Kappa
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抗原&靶点信息
免疫原:
The specific immunogen used to produce this antibody is proprietary information.
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特异性:
NF-M (Phospho Ser614/Ser619) Antibody detects endogenous levels of NF-M protein only when phosphorylated at S614/S619.The name of modified sites may be influenced by many factors, such as species (the modified site was not originally found in human samples) and the change of protein sequence (the previous protein sequence is incomplete, and the protein sequence may be prolonged with the development of protein sequencing technology). When naming, we will use the "numbers" in historical reference to keep the sites consistent with the reports. The antibody binds to the following modification sequence (lowercase letters are modification sites):KAkSP/VPkSP
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基因名称:
NEFM
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蛋白名称:
Neurofilament medium polypeptide
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别名:
NEFM ;
NEF3 ;
NFM ;
Neurofilament medium polypeptide ;
NF-M ;
160 kDa neurofilament protein ;
Neurofilament 3 ;
Neurofilament triplet M protein
NEF3 ;
NFM ;
Neurofilament medium polypeptide ;
NF-M ;
160 kDa neurofilament protein ;
Neurofilament 3 ;
Neurofilament triplet M protein
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背景:
neurofilament , medium polypeptide (NEFM) Homo sapiens Neurofilaments are type IV intermediate filament heteropolymers composed of light , medium , and heavy chains. Neurofilaments comprise the axoskeleton and functionally maintain neuronal caliber. They may also play a role in intracellular transport to axons and dendrites. This gene encodes the medium neurofilament protein. This protein is commonly used as a biomarker of neuronal damage. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq , Oct 2008] ,
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功能:
Function:Neurofilaments usually contain three intermediate filament proteins: L , M , and H which are involved in the maintenance of neuronal caliber. ,PTM:Phosphorylation seems to play a major role in the functioning of the larger neurofilament polypeptides (NF-M and NF-H) , the levels of phosphorylation being altered developmentally and coincident with a change in the neurofilament function. ,PTM:There are a number of repeats of the tripeptide K-S-P , NFM is phosphorylated on a number of the serines in this motif. It is thought that phosphorylation of NFM results in the formation of interfilament cross bridges that are important in the maintenance of axonal caliber. ,similarity:Belongs to the intermediate filament family. ,
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细胞定位:
Cytoplasm , cytoskeleton . Cell projection , axon .
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组织表达:
研究领域:
>>Amyotrophic lateral sclerosis ;
>>Pathways of neurodegeneration - multiple diseases
>>Pathways of neurodegeneration - multiple diseases
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信号通路
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货号: YM9286
规格
价格
货期
数量
200μL
￥3,580.00
现货
0
100μL
￥1,960.00
现货
0
40μL
￥960.00
现货
0
加入购物车
已收藏
收藏
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