Cofilin (Phospho Ser3) (PT0749R) PT™ Rabbit mAb
-YM8732
主要信息
Target
Cofilin Phospho Ser3
Host Species
Rabbit
Reactivity
Human, Mouse, Rat
Applications
WB, IF, ELISA
MW
19kD (Calculated)
25kD (Observed)
Conjugate/Modification
phosphate
货号: YM8732
规格
价格
货期
数量
200μL
￥3,580.00
现货
0
100μL
￥1,960.00
现货
0
40μL
￥960.00
现货
0
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详细信息
推荐稀释比
WB 1:500-1:2000; IF 1:200-1:1000; ELISA 1:5000-1:20000
组成
PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
特异性
Cofilin (Phospho Ser3) Antibody detects endogenous levels of Cofilin protein only when phosphorylated at S3.The name of modified sites may be influenced by many factors, such as species (the modified site was not originally found in human samples) and the change of protein sequence (the previous protein sequence is incomplete, and the protein sequence may be prolonged with the development of protein sequencing technology). When naming, we will use the "numbers" in historical reference to keep the sites consistent with the reports. The antibody binds to the following modification sequence (lowercase letters are modification sites):MAsGV
纯化工艺
Recombinant Antibody expressed in animal component-free (ACF) media, purified via Protein A affinity chromatography.
储存
-15°C to -25°C/1 year (Do not lower than -25°C)
理论分子量
19kD
实测条带
25kD
修饰
phosphate
克隆性
Monoclonal
克隆号
PT0749R
同种型
IgG, Kappa
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抗原&靶点信息
免疫原:
The specific immunogen used to produce this antibody is proprietary information.
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种属预测:
以下所列种属仅供参考。建议仅在目标物种与免疫原序列同源性高于80%时尝试用于WB等实验。由于蛋白表达存在种属、组织或细胞差异，即使同源性较高，实际效果仍需实验验证。本预测基于序列比对，结果仅供参考，不作为质保依据。
Homolo ≥ 90%
80% ≤ Homolo < 90%
0% < Homolo < 80%
特异性:
Cofilin (Phospho Ser3) Antibody detects endogenous levels of Cofilin protein only when phosphorylated at S3.The name of modified sites may be influenced by many factors, such as species (the modified site was not originally found in human samples) and the change of protein sequence (the previous protein sequence is incomplete, and the protein sequence may be prolonged with the development of protein sequencing technology). When naming, we will use the "numbers" in historical reference to keep the sites consistent with the reports. The antibody binds to the following modification sequence (lowercase letters are modification sites):MAsGV
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基因名称:
CFL1
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蛋白名称:
Cofilin-1
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别名:
CFL1 ;
CFL ;
Cofilin-1 ;
18 kDa phosphoprotein ;
p18 ;
Cofilin ;
non-muscle isoform
CFL ;
Cofilin-1 ;
18 kDa phosphoprotein ;
p18 ;
Cofilin ;
non-muscle isoform
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背景:
cofilin 1 (CFL1) Homo sapiens The protein encoded by this gene can polymerize and depolymerize F-actin and G-actin in a pH-dependent manner. Increased phosphorylation of this protein by LIM kinase aids in Rho-induced reorganization of the actin cytoskeleton. Cofilin is a widely distributed intracellular actin-modulating protein that binds and depolymerizes filamentous F-actin and inhibits the polymerization of monomeric G-actin in a pH-dependent manner. It is involved in the translocation of actin-cofilin complex from cytoplasm to nucleus.[supplied by OMIM , Apr 2004] ,
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功能:
Function:Controls reversibly actin polymerization and depolymerization in a pH-sensitive manner. It has the ability to bind G- and F-actin in a 1:1 ratio of cofilin to actin. It is the major component of intranuclear and cytoplasmic actin rods. ,online information:Cofilin entry ,PTM:Phosphorylated on Ser-3 in resting cells. ,similarity:Belongs to the actin-binding proteins ADF family. ,similarity:Contains 1 ADF-H domain. ,subcellular location:Almost completely in nucleus in cells exposed to heat shock or 10% dimethyl sulfoxide. ,tissue specificity:Widely distributed in various tissues. ,
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细胞定位:
Nucleus matrix . Cytoplasm , cytoskeleton . Cell projection , ruffle membrane ; Peripheral membrane protein ; Cytoplasmic side . Cell projection , lamellipodium membrane ; Peripheral membrane protein ; Cytoplasmic side . Cell projection , lamellipodium . Cell projection , growth cone . Cell projection , axon . Colocalizes with the actin cytoskeleton in membrane ruffles and lamellipodia. Detected at the cleavage furrow and contractile ring during cytokinesis. Almost completely in nucleus in cells exposed to heat shock or 10% dimethyl sulfoxide.
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组织表达:
研究领域:
>>Axon guidance ;
>>Fc gamma R-mediated phagocytosis ;
>>Regulation of actin cytoskeleton ;
>>Pertussis ;
>>Human immunodeficiency virus 1 infection
>>Fc gamma R-mediated phagocytosis ;
>>Regulation of actin cytoskeleton ;
>>Pertussis ;
>>Human immunodeficiency virus 1 infection
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信号通路
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货号: YM8732
规格
价格
货期
数量
200μL
￥3,580.00
现货
0
100μL
￥1,960.00
现货
0
40μL
￥960.00
现货
0
加入购物车
已收藏
收藏
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