Cdc25C (Phospho Ser216) (PT1382R) PT™ Rabbit mAb
-YM9224
主要信息
Target
Cdc25C Phospho Ser216
Host Species
Rabbit
Reactivity
Human, Mouse
Applications
WB, IHC, IF, IP, ELISA
MW
53kD (Calculated)
58kD (Observed)
Conjugate/Modification
phosphate
货号: YM9224
规格
价格
货期
数量
200μL
￥3,580.00
现货
0
100μL
￥1,960.00
现货
0
40μL
￥960.00
现货
0
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详细信息
推荐稀释比
IHC 1:200-1:1000; WB 1:500-1:2000; IF 1:200-1:1000; ELISA 1:5000-1:20000; IP 1:50-1:200
组成
PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
特异性
Cdc25C (Phospho Ser216) Antibody detects endogenous levels of Cdc25C protein only when phosphorylated at S216.The name of modified sites may be influenced by many factors, such as species (the modified site was not originally found in human samples) and the change of protein sequence (the previous protein sequence is incomplete, and the protein sequence may be prolonged with the development of protein sequencing technology). When naming, we will use the "numbers" in historical reference to keep the sites consistent with the reports. The antibody binds to the following modification sequence (lowercase letters are modification sites):SPsMP
纯化工艺
Recombinant Antibody expressed in animal component-free (ACF) media, purified via Protein A affinity chromatography.
储存
-15°C to -25°C/1 year (Do not lower than -25°C)
理论分子量
53kD
实测条带
58kD
修饰
phosphate
克隆性
Monoclonal
克隆号
PT1382R
同种型
IgG, Kappa
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抗原&靶点信息
免疫原:
The specific immunogen used to produce this antibody is proprietary information.
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种属预测:
以下所列种属仅供参考。建议仅在目标物种与免疫原序列同源性高于80%时尝试用于WB等实验。由于蛋白表达存在种属、组织或细胞差异，即使同源性较高，实际效果仍需实验验证。本预测基于序列比对，结果仅供参考，不作为质保依据。
Homolo ≥ 90%
80% ≤ Homolo < 90%
0% < Homolo < 80%
特异性:
Cdc25C (Phospho Ser216) Antibody detects endogenous levels of Cdc25C protein only when phosphorylated at S216.The name of modified sites may be influenced by many factors, such as species (the modified site was not originally found in human samples) and the change of protein sequence (the previous protein sequence is incomplete, and the protein sequence may be prolonged with the development of protein sequencing technology). When naming, we will use the "numbers" in historical reference to keep the sites consistent with the reports. The antibody binds to the following modification sequence (lowercase letters are modification sites):SPsMP
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基因名称:
CDC25C
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蛋白名称:
M-phase inducer phosphatase 3
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别名:
CDC25C ;
M-phase inducer phosphatase 3 ;
Dual specificity phosphatase Cdc25C
M-phase inducer phosphatase 3 ;
Dual specificity phosphatase Cdc25C
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背景:
cell division cycle 25C (CDC25C) Homo sapiens This gene encodes a conserved protein that plays a key role in the regulation of cell division. The encoded protein directs dephosphorylation of cyclin B-bound CDC2 and triggers entry into mitosis. It also suppresses p53-induced growth arrest. Multiple alternatively spliced transcript variants of this gene have been described. [provided by RefSeq , Dec 2015] ,
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功能:
Catalytic activity:Protein tyrosine phosphate + H (2) O = protein tyrosine + phosphate. ,developmental stage:Expressed predominantly in G2 phase. ,Function:Functions as a dosage-dependent inducer in mitotic control. It is a tyrosine protein phosphatase required for progression of the cell cycle. It directly dephosphorylates CDC2 and activate its kinase activity. ,PTM:Phosphorylated by CHK1 on Ser-216. This phosphorylation creates a binding site for 14-3-3 protein and inhibits the phosphatase. ,similarity:Belongs to the MPI phosphatase family. ,similarity:Contains 1 rhodanese domain. ,subunit:Interacts with HIV-1 Vpr , thereby inactivating CDC25C phosphatase activity. ,
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细胞定位:
Nucleus .
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组织表达:
研究领域:
>>Cell cycle ;
>>Oocyte meiosis ;
>>Progesterone-mediated oocyte maturation ;
>>Human immunodeficiency virus 1 infection ;
>>MicroRNAs in cancer
>>Oocyte meiosis ;
>>Progesterone-mediated oocyte maturation ;
>>Human immunodeficiency virus 1 infection ;
>>MicroRNAs in cancer
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信号通路
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货号: YM9224
规格
价格
货期
数量
200μL
￥3,580.00
现货
0
100μL
￥1,960.00
现货
0
40μL
￥960.00
现货
0
加入购物车
已收藏
收藏
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