InVivo Anti-Mouse CD8a/Lyt2 Antibody (2.43)
-YV0023
主要信息
Target
CD8
Host Species
Rat
Reactivity
Mouse
Applications
In vivo
货号: YV0023
规格
价格
货期
数量
100mg
￥39,000.00
一周
0
50mg
￥28,000.00
一周
0
25mg
￥18,000.00
一周
0
5mg
￥5,500.00
一周
0
1mg
￥1,500.00
一周
0
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详细信息
组成
0.01M PBS, pH 7.4.
纯化工艺
Protein A/G purified from cell culture supernatant.
纯度
Endotoxin level <1 EU/mg. Purity>95% as determined by SDS-PAGE.
储存
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
浓度
Lot depended
克隆性
Monoclonal
同种型
lgG2b
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抗原&靶点信息
基因名称:
CD8A MAL
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蛋白名称:
T-cell surface glycoprotein CD8 alpha chain (T-lymphocyte differentiation antigen T8/Leu-2) (CD antigen CD8a)
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别名:
T-cell surface glycoprotein CD8 alpha chain ;
T-lymphocyte differentiation antigen T8/Leu-2 ;
CD antigen CD8a ;
CD8 nanobody ;
T-lymphocyte differentiation antigen T8/Leu-2 ;
CD antigen CD8a ;
CD8 nanobody ;
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背景:
The CD8 antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system. The CD8 antigen acts as a coreceptor with the T-cell receptor on the T lymphocyte to recognize antigens displayed by an antigen presenting cell in the context of class I MHC molecules. The coreceptor functions as either a homodimer composed of two alpha chains or as a heterodimer composed of one alpha and one beta chain. Both alpha and beta chains share significant homology to immunoglobulin variable light chains.This gene encodes the CD8 alpha chain. Multiple transcript variants encoding different isoforms have been found forThis gene. [provided by RefSeq , Nov 2011]
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功能:
Disease:Defects in CD8A are a cause of familial CD8 deficiency (CD8 deficiency) [MIM:608957]. Familial CD8 deficiency is a novel autosomal recessive immunologic defect characterized by absence of CD8+ cells , leading to recurrent bacterial infections. ,Identifies cytotoxic/suppressor T-cells that interact with MHC class I bearing targets. CD8 is thought to play a role in the process of T-cell mediated killing. CD8 alpha chains binds to class I MHC molecules alpha-3 domains. ,online information:CD8 entry ,online information:CD8A mutation db ,PTM:All of the five most carboxyl-terminal cysteines form inter-chain disulfide bonds in dimers and higher multimers , while the four N-terminal cysteines do not. ,similarity:Contains 1 Ig-like V-type (immunoglobulin-like) domain. ,subunit:In general heterodimer of an alpha and a beta chain linked by two disulfide bonds. Can also form homodimers. Shown to be expressed as heterdimer on thymocytes and as homodimer on peripheral blood T-lymphocytes. Interacts with the MHC class I HLA-A/B2M dimer. Interacts with LCK in a zinc-dependent manner. ,
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细胞定位:
[Isoform 1]: Cell membrane ; Single-pass type I membrane protein. CD8A localizes to lipid rafts only when associated with its partner CD8B. .; [Isoform 2]: Secreted .
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研究领域:
For research use only.
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信号通路
Organismal Systems >> Immune system >> Hematopoietic cell lineage
Organismal Systems >> Immune system >> Antigen processing and presentation
Organismal Systems >> Immune system >> T cell receptor signaling pathway
Human Diseases >> Immune disease >> Primary immunodeficiency
Environmental Information Processing >> Signaling molecules and interaction >> Cell adhesion molecules
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货号: YV0023
规格
价格
货期
数量
100mg
￥39,000.00
一周
0
50mg
￥28,000.00
一周
0
25mg
￥18,000.00
一周
0
5mg
￥5,500.00
一周
0
1mg
￥1,500.00
一周
0
加入购物车
已收藏
收藏
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