Stromal Interaction Molecule 1 Rabbit pAb
-YT8094
主要信息
Target
Stromal Interaction Molecule 1
Host Species
Rabbit
Reactivity
Human, Mouse, Rat
Applications
WB, IHC
MW
75kD (Calculated)
Conjugate/Modification
Unmodified
货号: YT8094
规格
价格
货期
数量
200μL
￥3,780.00
一个月
0
100μL
￥2,300.00
一个月
0
40μL
￥960.00
一个月
0
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详细信息
推荐稀释比
WB 1:500-2000; IHC 1:50-200
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
特异性
This antibody detects endogenous levels of STIM1 at Human, Mouse,Rat
纯化工艺
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存
-15°C to -25°C/1 year (Do not lower than -25°C)
浓度
1 mg/ml
理论分子量
75kD
修饰
Unmodified
克隆性
Polyclonal
同种型
IgG
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抗原&靶点信息
免疫原:
Synthesized peptide derived from human N-ternal STIM1. AA range:25-105
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特异性:
This antibody detects endogenous levels of STIM1 at Human, Mouse,Rat
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基因名称:
STIM1 GOK
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蛋白名称:
Stromal interaction molecule 1
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别名:
Stromal interaction molecule 1
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背景:
This gene encodes a type 1 transmembrane protein that mediates Ca2+ influx after depletion of intracellular Ca2+ stores by gating of store-operated Ca2+ influx channels (SOCs) . It is one of several genes located in the imprinted gene domain of 11p15.5 , an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome , Wilms tumor , rhabdomyosarcoma , adrenocrotical carcinoma , and lung , ovarian , and breast cancer. This gene may play a role in malignancies and disease that involve this region , as well as early hematopoiesis , by mediating attachment to stromal cells. Mutations in this gene are associated with fatal classic Kaposi sarcoma , immunodeficiency due to defects in store-operated calcium entry (SOCE) in fibroblasts , ectodermal dysplasia and tubular aggregate myopathy. This gene is oriented in a head-to-tail configuration with the ribonucleotide reductase 1 gene (RRM1) , with the 3' end of this gene situated 1.6 kb from the 5' end of the RRM1 gene. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq , May 2013]
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功能:
Plays a role in mediating store-operated Ca (2+) entry (SOCE) , a Ca (2+) influx following depletion of intracellular Ca (2+) stores . Acts as Ca (2+) sensor in the endoplasmic reticulum via its EF-hand domain. Upon Ca (2+) depletion , translocates from the endoplasmic reticulum to the plasma membrane where it activates the Ca (2+) release-activated Ca (2+) (CRAC) channel subunit ORAI1 . Involved in enamel formation . Activated following interaction with STIMATE , leading to promote STIM1 conformational switch .
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细胞定位:
Cell membrane; Single-pass type I membrane protein . Endoplasmic reticulum membrane; Single-pass type I membrane protein . Cytoplasm , cytoskeleton . Sarcoplasmic reticulum . Translocates from the endoplasmic reticulum to the cell membrane in response to a depletion of intracellular calcium and is detected at punctae corresponding to junctions between the endoplasmic reticulum and the cell membrane (PubMed:19249086 , PubMed:16005298 , PubMed:16208375 , PubMed:18854159) . Associated with the microtubule network at the growing distal tip of microtubules (PubMed:19632184) . Colocalizes with ORAI1 at the cell membrane (PubMed:27185316) . Colocalizes preferentially with CASQ1 at endoplasmic reticulum in response to a depletion of intracellular calcium (PubMed:27185316) . .
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信号通路
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货号: YT8094
规格
价格
货期
数量
200μL
￥3,780.00
一个月
0
100μL
￥2,300.00
一个月
0
40μL
￥960.00
一个月
0
加入购物车
已收藏
收藏
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