Synthesized peptide derived from human PRGC2 AA range: 829-879

This antibody detects endogenous levels of PRGC2 at Human/Mouse/Rat

PPARGC1B

Peroxisome proliferator-activated receptor gamma coactivator 1-beta

PPARGC1B PERC PGC1 PGC1B PPARGC1

The protein encoded by this gene stimulates the activity of several transcription factors and nuclear receptors , including estrogen receptor alpha , nuclear respiratory factor 1 , and glucocorticoid receptor. The encoded protein may be involved in fat oxidation , non-oxidative glucose metabolism , and the regulation of energy expenditure. This protein is downregulated in prediabetic and type 2 diabetes mellitus patients. Certain allelic variations in this gene increase the risk of the development of obesity. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq , Mar 2010] ,

Domain:Contains 2 Leu-Xaa-Xaa-Leu-Leu (LXXLL) motif , which are usually required for the association with nuclear receptors. ,Function:Plays a role of stimulator of transcription factors and nuclear receptors activities. Activates transcritional activity of estrogen receptor alpha , nuclear respiratory factor 1 (NRF1) and glucocorticoid receptor in the presence of glucocorticoids. May play a role in constitutive non-adrenergic-mediated mitochondrial biogenesis as suggested by increased basal oxygen consumption and mitochondrial number when overexpressed. May be involved in fat oxidation and non-oxidative glucose metabolism and in the regulation of energy expenditure. ,induction:Repressed by saturated fatty acids such as palmitate and stearate in skeletal muscle cells. Induced by insulin and reduced by aging in skeletal muscle biopsies. Down-regulated in type 2 diabetes mellitus subjects as well as in pre-diabetics. ,polymorphism:Variation of PPARGC1B may contribute to the pathogenesis of obesity , with a widespread Ala-203 allele being a risk factor for the development of this common disorders. ,similarity:Contains 1 RRM (RNA recognition motif) domain. ,subunit:Interacts with hepatocyte nuclear factor 4-alpha/HNF4A , Sterol regulatory binding transcription factor 1/SREBF1 , PPAR-alpha/PPARA , thyroid hormone receptor beta/THRB and host cell factor/HCFC1. Interacts with estrogen-related receptor gamma/ESRRG and alpha/ESRRA (By similarity) . Interacts with estrogen receptor alpha/ESR1. ,tissue specificity:Ubiquitous with higher expression in heart , brain and skeletal muscle. ,

Nucleus .

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