Glutamine Synthetase Rabbit pAb
-YT5035
主要信息
Target
Glutamine synthetase
Host Species
Rabbit
Reactivity
Human, Mouse, Rat
Applications
WB, ELISA
MW
42kD (Observed)
Conjugate/Modification
Unmodified
货号: YT5035
规格
价格
货期
数量
200μL
￥3,780.00
一个月
0
100μL
￥2,300.00
一个月
0
40μL
￥960.00
一个月
0
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详细信息
推荐稀释比
WB 1:500-1:2000; ELISA 1:20000; Not yet tested in other applications.
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
特异性
Gl Syn Polyclonal Antibody detects endogenous levels of Gl Syn protein.
纯化工艺
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存
-15°C to -25°C/1 year (Do not lower than -25°C)
浓度
1 mg/ml
实测条带
42kD
修饰
Unmodified
克隆性
Polyclonal
同种型
IgG
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抗原&靶点信息
免疫原:
The antiserum was produced against synthesized peptide derived from human Gl Syn. AA range:295-344
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特异性:
Gl Syn Polyclonal Antibody detects endogenous levels of Gl Syn protein.
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基因名称:
GLUL
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蛋白名称:
Glutamine synthetase
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别名:
GLUL ;
GLNS ;
Glutamine synthetase ;
GS ;
Glutamate decarboxylase ;
Glutamate--ammonia ligase
GLNS ;
Glutamine synthetase ;
GS ;
Glutamate decarboxylase ;
Glutamate--ammonia ligase
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背景:
The protein encoded by this gene belongs to the glutamine synthetase family. It catalyzes the synthesis of glutamine from glutamate and ammonia in an ATP-dependent reaction. This protein plays a role in ammonia and glutamate detoxification , acid-base homeostasis , cell signaling , and cell proliferation. Glutamine is an abundant amino acid , and is important to the biosynthesis of several amino acids , pyrimidines , and purines. Mutations in this gene are associated with congenital glutamine deficiency , and overexpression of this gene was observed in some primary liver cancer samples. There are six pseudogenes of this gene found on chromosomes 2 , 5 , 9 , 11 , and 12. Alternative splicing results in multiple transcript variants. [provided by RefSeq , Dec 2014] ,
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功能:
Catalytic activity:ATP + L-glutamate + NH (3) = ADP + phosphate + L-glutamine. ,Disease:Defects in GLUL are the cause of congenital systemic glutamine deficiency (CSGD) [MIM:610015]. CSGD is a rare developmental disorder with severe brain malformation resulting in multi-organ failure and neonatal death. Glutamine is largely absent from affected patients serum , urine and cerebrospinal fluid. ,online information:Glutamine synthetase entry ,similarity:Belongs to the glutamine synthetase family. ,subunit:Homooctamer. ,
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细胞定位:
Cytoplasm , cytosol . Microsome . Mitochondrion . Cell membrane ; Lipid-anchor . Mainly localizes in the cytosol , with a fraction associated with the cell membrane. .
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组织表达:
研究领域:
>>Arginine biosynthesis ;
>>Alanine , aspartate and glutamate metabolism ;
>>Glyoxylate and dicarboxylate metabolism ;
>>Nitrogen metabolism ;
>>Metabolic pathways ;
>>Biosynthesis of amino acids ;
>>Necroptosis ;
>>Glutamatergic synapse ;
>>GABAergic synapse
>>Alanine , aspartate and glutamate metabolism ;
>>Glyoxylate and dicarboxylate metabolism ;
>>Nitrogen metabolism ;
>>Metabolic pathways ;
>>Biosynthesis of amino acids ;
>>Necroptosis ;
>>Glutamatergic synapse ;
>>GABAergic synapse
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信号通路
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货号: YT5035
规格
价格
货期
数量
200μL
￥3,780.00
一个月
0
100μL
￥2,300.00
一个月
0
40μL
￥960.00
一个月
0
加入购物车
已收藏
收藏
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