Cathepsin D Rabbit pAb
-YT0680
主要信息
Target
Cathepsin D
Host Species
Rabbit
Reactivity
Human, Mouse
Applications
WB, IHC, IF, ELISA
MW
44kD (Observed)
Conjugate/Modification
Unmodified
货号: YT0680
规格
价格
货期
数量
200μL
￥3,780.00
一个月
0
100μL
￥2,300.00
一个月
0
40μL
￥960.00
一个月
0
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详细信息
推荐稀释比
WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:5000; IF 1:50-200
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
特异性
Cathepsin D Polyclonal Antibody detects endogenous levels of Cathepsin D protein.
纯化工艺
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存
-15°C to -25°C/1 year (Do not lower than -25°C)
浓度
1 mg/ml
实测条带
44kD
修饰
Unmodified
克隆性
Polyclonal
同种型
IgG
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抗原&靶点信息
免疫原:
Synthesized peptide derived from the Internal region of human Cathepsin D .. AA range:86-156
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特异性:
Cathepsin D Polyclonal Antibody detects endogenous levels of Cathepsin D protein.
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基因名称:
CTSD
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蛋白名称:
Cathepsin D
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别名:
CTSD ;
CPSD ;
Cathepsin D
CPSD ;
Cathepsin D
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背景:
This gene encodes a member of the A1 family of peptidases. The encoded preproprotein is proteolytically processed to generate multiple protein products. These products include the cathepsin D light and heavy chains , which heterodimerize to form the mature enzyme. This enzyme exhibits pepsin-like activity and plays a role in protein turnover and in the proteolytic activation of hormones and growth factors. Mutations in this gene play a causal role in neuronal ceroid lipofuscinosis-10 and may be involved in the pathogenesis of several other diseases , including breast cancer and possibly Alzheimer's disease. [provided by RefSeq , Nov 2015] ,
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功能:
Catalytic activity:Specificity similar to , but narrower than , that of pepsin A. Does not cleave the 4-Gln-|-His-5 bond in B chain of insulin. ,Disease:Defects in CTSD are the cause of neuronal ceroid lipofuscinosis 10 (CLN10) [MIM:610127]; also known as neuronal ceroid lipofuscinosis due to cathepsin D deficiency. The neuronal ceroid lipofuscinosis are a group of progressive neurodegenerative diseases in children and in adults , characterized by visual and mental decline , motor disturbance , epilepsy and behavioral changes. ,Function:Acid protease active in intracellular protein breakdown. Involved in the pathogenesis of several diseases such as breast cancer and possibly Alzheimer disease. ,polymorphism:The Val-58 allele is significantly overrepresented in demented patients (11.8%) compared with non-demented controls (4.9%) . Carriers of the Val-58 allele have a 3.1-fold increased risk for developing AD than non-carriers. ,similarity:Belongs to the peptidase A1 family. ,subcellular location:Identified by mass spectrometry in melanosome fractions from stage I to stage IV. ,subunit:Consists of a light chain and a heavy chain. ,
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细胞定位:
Lysosome. Melanosome. Secreted , extracellular space. Identified by mass spectrometry in melanosome fractions from stage I to stage IV. In aortic samples , detected as an extracellular protein loosely bound to the matrix (PubMed:20551380) . .
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研究领域:
>>Sphingolipid signaling pathway ;
>>Autophagy - animal ;
>>Lysosome ;
>>Apoptosis ;
>>Estrogen signaling pathway ;
>>Tuberculosis ;
>>Diabetic cardiomyopathy
>>Autophagy - animal ;
>>Lysosome ;
>>Apoptosis ;
>>Estrogen signaling pathway ;
>>Tuberculosis ;
>>Diabetic cardiomyopathy
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信号通路
Cellular Processes >> Transport and catabolism >> Lysosome
Cellular Processes >> Transport and catabolism >> Autophagy - animal
Cellular Processes >> Cell growth and death >> Apoptosis
Organismal Systems >> Endocrine system >> Estrogen signaling pathway
Environmental Information Processing >> Signal transduction >> Sphingolipid signaling pathway
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货号: YT0680
规格
价格
货期
数量
200μL
￥3,780.00
一个月
0
100μL
￥2,300.00
一个月
0
40μL
￥960.00
一个月
0
加入购物车
已收藏
收藏
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