The antiserum was produced against synthesized peptide derived from human VEGFR1. AA range:1016-1065

Flt-1 Polyclonal Antibody detects endogenous levels of Flt-1 protein.

FLT1

Vascular endothelial growth factor receptor 1

FLT1 ;
FLT ;
FRT ;
VEGFR1 ;
Vascular endothelial growth factor receptor 1 ;
VEGFR-1 ;
Fms-like tyrosine kinase 1 ;
FLT-1 ;
Tyrosine-protein kinase FRT ;
Tyrosine-protein kinase receptor FLT ;
FLT ;
Vascular permeability factor receptor

This gene encodes a member of the vascular endothelial growth factor receptor (VEGFR) family. VEGFR family members are receptor tyrosine kinases (RTKs) which contain an extracellular ligand-binding region with seven immunoglobulin (Ig) -like domains , a transmembrane segment , and a tyrosine kinase (TK) domain within the cytoplasmic domain. This protein binds to VEGFR-A , VEGFR-B and placental growth factor and plays an important role in angiogenesis and vasculogenesis. Expression of this receptor is found in vascular endothelial cells , placental trophoblast cells and peripheral blood monocytes. Multiple transcript variants encoding different isoforms have been found for this gene. Isoforms include a full-length transmembrane receptor isoform and shortened , soluble isoforms. The soluble isoforms are associated with the onset of pre-eclampsia.[provided by RefSeq , May 2009] ,

Alternative products:Additional isoforms seem to exist ,Catalytic activity:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate. ,Function:Receptor for VEGF , VEGFB and PGF. Has a tyrosine-protein kinase activity. The VEGF-kinase ligand/receptor signaling system plays a key role in vascular development and regulation of vascular permeability. Isoform SFlt1 may have an inhibitory role in angiogenesis. ,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family. ,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. ,similarity:Contains 1 protein kinase domain. ,similarity:Contains 7 Ig-like C2-type (immunoglobulin-like) domains. ,subunit:Interacts in vitro with various phosphotyrosine-binding proteins , including PLC-gammas , PTPN11 , GRB2 , CRK and NCK1. ,tissue specificity:Mostly in normal lung , but also in placenta , liver , kidney , heart and brain tissues. Specifically expressed in most of the vascular endothelial cells , and also expressed in peripheral blood monocytes. It is not expressed in tumor cell lines. Isoform sFlt1 is strongly expressed in placenta. ,

[Isoform 1]: Cell membrane; Single-pass type I membrane protein. Endosome. Autophosphorylation promotes ubiquitination and endocytosis.; [Isoform 2]: Secreted .; [Isoform 3]: Secreted.; [Isoform 4]: Secreted.; [Isoform 5]: Cytoplasm .; [Isoform 6]: Cytoplasm .; [Isoform 7]: Cytoplasm .

>>MAPK signaling pathway ;
>>Ras signaling pathway ;
>>Rap1 signaling pathway ;
>>Calcium signaling pathway ;
>>HIF-1 signaling pathway ;
>>PI3K-Akt signaling pathway ;
>>Focal adhesion ;
>>Transcriptional misregulation in cancer ;
>>Rheumatoid arthritis