Synthetic Peptide of CaMKIIβ/γ/δ (Phospho Thr287)

CaMKIIβ/γ/δ (Phospho Thr287) protein detects endogenous levels of CaMKIIβ/γ/δ (Phospho Thr287)

CAMK2B

Calcium/calmodulin-dependent protein kinase type II subunit beta

CAMK2B ;
CAM2 ;
CAMK2 ;
CAMKB ;
Calcium/calmodulin-dependent protein kinase type II subunit beta ;
CaM kinase II subunit beta ;
CaMK-II subunit beta ;
CAMK2G ;
CAMK ;
CAMK-II ;
CAMKG ;
Calcium/calmodulin-dependent protein kinase type II subunit gamma ;

The product of this gene belongs to the serine/threonine protein kinase family and to the Ca (2+) /calmodulin-dependent protein kinase subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. In mammalian cells , the enzyme is composed of four different chains: alpha , beta , gamma , and delta. The product of this gene is a beta chain. It is possible that distinct isoforms of this chain have different cellular localizations and interact differently with calmodulin. Alternative splicing results in multiple transcript variants. [provided by RefSeq , May 2014] ,

Alternative products:The variable region of the CAMK2B protein is encoded by at least 7 exons (V1 to V7) . Alternative splicing within this region gives rise to CAMK2B isoforms ,Catalytic activity:ATP + a protein = ADP + a phosphoprotein. ,enzyme regulation:Autophosphorylation of CAMK2 plays an important role in the regulation of the kinase activity. ,Function:CaM-kinase II (CAMK2) is a prominent kinase in the central nervous system that may function in long-term potentiation and neurotransmitter release. Member of the NMDAR signaling complex in excitatory synapses , it may regulate NMDAR-dependent potentiation of the AMPAR and synaptic plasticity. ,similarity:Belongs to the protein kinase superfamily. ,similarity:Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily. ,similarity:Contains 1 protein kinase domain. ,subunit:CAMK2 is composed of four different chains: alpha , beta , gamma , and delta. The different isoforms assemble into homo- or heteromultimeric holoenzymes composed of 8 to 12 subunits. Interacts with SYNGAP1 and CAMK2N2 (By similarity) . Interacts with MPDZ. ,tissue specificity:Widely expressed. Expressed in adult and fetal brain. Expression is slightly lower in fetal brain. ,

Cytoplasm , cytoskeleton . Cytoplasm , cytoskeleton , microtubule organizing center , centrosome . Sarcoplasmic reticulum membrane ; Peripheral membrane protein ; Cytoplasmic side . Cell junction , synapse . In slow-twitch muscle , evenly distributed between longitudinal SR and junctional SR.

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