The antiserum was produced against synthesized peptide derived from human p21 Cip1. AA range:111-160

p21 Polyclonal Antibody detects endogenous levels of p21 protein.

CDKN1A CAP20 CDKN1 CIP1 MDA6 PIC1 SDI1 WAF1

Cyclin-dependent kinase inhibitor 1

CDKN1A ;
CAP20 ;
CDKN1 ;
CIP1 ;
MDA6 ;
PIC1 ;
SDI1 ;
WAF1 ;
Cyclin-dependent kinase inhibitor 1 ;
CDK-interacting protein 1 ;
Melanoma differentiation-associated protein 6 ;
MDA-6 ;
p21 ;

This gene encodes a potent cyclin-dependent kinase inhibitor. The encoded protein binds to and inhibits the activity of cyclin-cyclin-dependent kinase2 or -cyclin-dependent kinase4 complexes , and thus functions as a regulator of cell cycle progression at G1. The expression of this gene is tightly controlled by the tumor suppressor protein p53 , through which this protein mediates the p53-dependent cell cycle G1 phase arrest in response to a variety of stress stimuli. This protein can interact with proliferating cell nuclear antigen , a DNA polymerase accessory factor , and plays a regulatory role in S phase DNA replication and DNA damage repair. This protein was reported to be specifically cleaved by CASP3-like caspases , which thus leads to a dramatic activation of cyclin-dependent kinase2 , and may be instrumental in the execution of apoptosis following caspase activation. Mice that lac

Function:May be the important intermediate by which p53 mediates its role as an inhibitor of cellular proliferation in response to DNA damage. Binds to and inhibits cyclin-dependent kinase activity , preventing phosphorylation of critical cyclin-dependent kinase substrates and blocking cell cycle progression. ,induction:By p53 , mezerein (antileukemic compound) and interferon beta. ,PTM:Phosphorylation of Thr-145 by Akt or of Ser-146 by PKC impairs binding to PCNA. ,similarity:Belongs to the CDI family. ,tissue specificity:Expressed in all adult human tissues , with 5-fold lower levels observed in the brain. ,

Cytoplasm . Nucleus .

>>Endocrine resistance ;
>>Platinum drug resistance ;
>>ErbB signaling pathway ;
>>HIF-1 signaling pathway ;
>>FoxO signaling pathway ;
>>Cell cycle ;
>>p53 signaling pathway ;
>>PI3K-Akt signaling pathway ;
>>Cellular senescence ;
>>JAK-STAT signaling pathway ;
>>Oxytocin signaling pathway ;
>>Parathyroid hormone synthesis , secretion and action ;
>>Cushing syndrome ;
>>Hepatitis C ;
>>Hepatitis B ;
>>Human cytomegalovirus infection ;
>>Human papillomavirus infection ;
>>Human T-cell leukemia virus 1 infection ;
>>Kaposi sarcoma-associated herpesvirus infection ;
>>Epstein-Barr virus infection ;
>>Pathways in cancer ;
>>Transcriptional misregulation in cancer ;
>>Viral carcinogenesis ;
>>Proteoglycans in cancer ;
>>MicroRNAs in cancer ;
>>Colorectal cancer ;
>>Renal cell carcinoma ;
>>Pancreatic cancer ;
>>Endometrial cancer ;
>>Glioma ;
>>Prostate cancer ;
>>Thyroid cancer ;
>>Basal cell carcinoma ;
>>Melanoma ;
>>Bladder cancer ;
>>Chronic myeloid leukemia ;
>>Small cell lung cancer ;
>>Non-small cell lung cancer ;
>>Breast cancer ;
>>Hepatocellular carcinoma ;
>>Gastric cancer