Synthesized peptide derived from human OPTN. AA range:120-190

This antibody detects endogenous levels of OPTN at Human, Mouse,Rat

OPTN FIP2 GLC1E HIP7 HYPL NRP

OPTN

Optineurin ;
E3-14.7K-interacting protein ;
FIP-2 ;
Huntingtin yeast partner L ;
Huntingtin-interacting protein 7 ;
HIP-7 ;
Huntingtin-interacting protein L ;
NEMO-related protein ;
Optic neuropathy-inducing protein ;
Transcription factor IIIA-interacting protein ;
TFIIIA-IntP ;

This gene encodes the coiled-coil containing protein optineurin. Optineurin may play a role in normal-tension glaucoma and adult-onset primary open angle glaucoma. Optineurin interacts with adenovirus E3-14.7K protein and may utilize tumor necrosis factor-alpha or Fas-ligand pathways to mediate apoptosis , inflammation or vasoconstriction. Optineurin may also function in cellular morphogenesis and membrane trafficking , vesicle trafficking , and transcription activation through its interactions with the RAB8 , huntingtin , and transcription factor IIIA proteins. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq , Jul 2008]

Cytoplasm , perinuclear region. Golgi apparatus . Golgi apparatus , trans-Golgi network. Cytoplasmic vesicle , autophagosome. Cytoplasmic vesicle. Recycling endosome. Found in the perinuclear region and associates with the Golgi apparatus (PubMed:27534431) . Colocalizes with MYO6 and RAB8 at the Golgi complex and in vesicular structures close to the plasma membrane. Localizes to LC3-positive cytoplasmic vesicles upon induction of autophagy. .

>>Mitophagy - animal ;
>>Amyotrophic lateral sclerosis ;
>>Pathways of neurodegeneration - multiple diseases