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Cyclophilin B (2B10) Mouse mAb (Cy5)

-YM2025

主要信息
Target

Cyclophilin B

Host Species

Mouse

Reactivity

Human, Rat, Mouse

Applications

IF, WB, IHC,

Conjugate/Modification

Cy5
Unmodified

详细信息
推荐稀释比
Optimal working dilutions should be determined experimentally by the investigator; Suggested starting dilutions are as follows:IHC 1:50-300; IF 1:50-200.
组成
Liquid in PBS, pH 7.4, containing 0.02% sodium azide as preservative and 50% Glycerol.
特异性
Cyclophilin B Monoclonal Antibody(2B10) Cy5 Conjugated specially designed for your Immunofluorescence analysis.
纯化工艺
The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
储存
Stable for one year at -15°C to -25°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing. Store in dark.
浓度
1mg/ml
修饰
Unmodified
偶联
Cy5
克隆性
Monoclonal
克隆号
2B10
同种型
IgG
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抗原&靶点信息
特异性:
Cyclophilin B Monoclonal Antibody(2B10) Cy5 Conjugated specially designed for your Immunofluorescence analysis.
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基因名称:
PPIB
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蛋白名称:
Peptidyl-prolyl cis-trans isomerase B (PPIase B) (CYP-S1) (Cyclophilin B) (Rotamase B) (S-cyclophilin) (SCYLP)
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别名:
Cyclophilin B
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数据库链接:
Organism 基因 ID SwissProt
Human 5479; P23284;
背景:
The protein encoded by this gene is a cyclosporine-binding protein and is mainly located within the endoplasmic reticulum. It is associated with the secretory pathway and released in biological fluids. This protein can bind to cells derived from T- and B-lymphocytes, and may regulate cyclosporine A-mediated immunosuppression. Variants have been identified in this protein that give rise to recessive forms of osteogenesis imperfecta. [provided by RefSeq, Oct 2009],
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功能:
Catalytic activity:Peptidylproline (omega=180) = peptidylproline (omega=0).,Caution:It is uncertain whether Met-1 or Met-9 is the initiator.,enzyme regulation:Cyclosporin A (CsA) inhibits CYPB.,Function:PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.,similarity:Belongs to the cyclophilin-type PPIase family. PPIase B subfamily.,similarity:Contains 1 PPIase cyclophilin-type domain.,subcellular location:Identified by mass spectrometry in melanosome fractions from stage I to stage IV.,
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细胞定位:
Virion . (Microbial infection).; Endoplasmic reticulum lumen . Melanosome . Identified by mass spectrometry in melanosome fractions from stage I to stage IV (PubMed:17081065). .
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组织表达:
Brain,Fetal brain cortex,Prostate,Skin,
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