Fibrillarin Rabbit pAb
-YN5902
主要信息
Target
FBL
Host Species
Rabbit
Reactivity
Human, Mouse, Rat
Applications
WB
MW
35kD (Calculated)
Conjugate/Modification
Unmodified
货号: YN5902
规格
价格
货期
数量
200μL
￥3,780.00
一个月
0
100μL
￥2,300.00
一个月
0
40μL
￥960.00
一个月
0
加入购物车
已收藏
收藏
详细信息
推荐稀释比
WB 1:500-2000
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
特异性
This antibody detects endogenous levels of FBL at Human, Mouse,Rat
纯化工艺
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存
-15°C to -25°C/1 year (Do not lower than -25°C)
浓度
1 mg/ml
理论分子量
35kD
修饰
Unmodified
克隆性
Polyclonal
同种型
IgG
相关产品
Secondary Antibodies
Goat Anti Mouse IgG(H+L) (HRP)
RS0001
预览→
Secondary Antibodies
Goat Anti Rabbit IgG(H+L) (HRP)
RS0002
预览→
Primary Antibodies
β-actin (PTR2364) Mouse mAb
YM3028
预览→
Primary Antibodies
GAPDH (PTR2304) Mouse mAb
YM3029
预览→
抗原&靶点信息
免疫原:
Synthesized peptide derived from human FBL. AA range:1-38
展开内容
特异性:
This antibody detects endogenous levels of FBL at Human, Mouse,Rat
展开内容
基因名称:
FBL FIB1 FLRN
展开内容
蛋白名称:
rRNA 2'-O-methyltransferase fibrillarin (34 kDa nucleolar scleroderma antigen)
展开内容
背景:
This gene product is a component of a nucleolar small nuclear ribonucleoprotein (snRNP) particle thought to participate in the first step in processing preribosomal RNA. It is associated with the U3 , U8 , and U13 small nuclear RNAs and is located in the dense fibrillar component (DFC) of the nucleolus. The encoded protein contains an N-terminal repetitive domain that is rich in glycine and arginine residues , like fibrillarins in other species. Its central region resembles an RNA-binding domain and contains an RNP consensus sequence. Antisera from approximately 8% of humans with the autoimmune disease scleroderma recognize fibrillarin. [provided by RefSeq , Jul 2008]
展开内容
功能:
S-adenosyl-L-methionine-dependent methyltransferase that has the ability to methylate both RNAs and proteins . Involved in pre-rRNA processing by catalyzing the site-specific 2'-hydroxyl methylation of ribose moieties in pre-ribosomal RNA . Site specificity is provided by a guide RNA that base pairs with the substrate (By similarity) . Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA (By similarity) . Probably catalyzes 2'-O-methylation of U6 snRNAs in box C/D RNP complexes . U6 snRNA 2'-O-methylation is required for mRNA splicing fidelity . Also acts as a protein methyltransferase by mediating methylation of 'Gln-105' of histone H2A (H2AQ104me) , a modification that impairs binding of the FACT complex and is specifically present at 35S ribosomal DNA locus .
展开内容
细胞定位:
Nucleus , nucleolus . Nucleus , nucleoplasm . Fibrillar region of the nucleolus.
展开内容
文献引用（{{totalcount}}）
货号: YN5902
规格
价格
货期
数量
200μL
￥3,780.00
一个月
0
100μL
￥2,300.00
一个月
0
40μL
￥960.00
一个月
0
加入购物车
已收藏
收藏
Recently Viewed Products
Clear all
×
Toggle night Mode
{{pinfoXq.title || ''}}
Catalog: {{pinfoXq.catalog || ''}}
Filter：
All
{{item.name}}
{{pinfo.title}}
-{{pinfo.catalog}}
主要信息
Target
{{pinfo.target}}
Reactivity
{{pinfo.react}}
Applications
{{pinfo.applicat}}
Conjugate/Modification
{{pinfo.coupling}}/{{pinfo.modific}}
MW (kDa)
{{pinfo.mwcalc}}
Host Species
{{pinfo.hostspec}}
Isotype
{{pinfo.isotype}}
产品 {{index}}/{{pcount}}
上一个产品
下一个产品
{{pvTitle}}
滚轮缩放图片
{{pvDescr}}