Synthesized peptide derived from human UQCRC2. AA range:115-215

This antibody detects endogenous levels of UQCRC2 at Human, Mouse,Rat

UQCRC2

Cytochrome b-c1 complex subunit 2, mitochondrial (Complex III subunit 2) (Core protein II) (Ubiquinol-cytochrome-c reductase complex core protein 2)

The protein encoded by this gene is located in the mitochondrion , where it is part of the ubiquinol-cytochrome c reductase complex (also known as complex III) . This complex constitutes a part of the mitochondrial respiratory chain. Defects in this gene are a cause of mitochondrial complex III deficiency nuclear type 5. [provided by RefSeq , Jul 2015]

Component of the ubiquinol-cytochrome c oxidoreductase , a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II , CII) , ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex , complex III , CIII) and cytochrome c oxidase (complex IV , CIV) , that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen , creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c , linking this redox reaction to translocation of protons across the mitochondrial inner membrane , with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle , 2 protons are consumed from the matrix , 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c (By similarity) . The 2 core subunits UQCRC1/QCR1 and UQCRC2/QCR2 are homologous to the 2 mitochondrial-processing peptidase (MPP) subunits beta-MPP and alpha-MPP respectively , and they seem to have preserved their MPP processing properties (By similarity) . May be involved in the in situ processing of UQCRFS1 into the mature Rieske protein and its mitochondrial targeting sequence (MTS) /subunit 9 when incorporated into complex III (Probable) .

Mitochondrion inner membrane ; Peripheral membrane protein ; Matrix side .