The specific immunogen used to produce this antibody is proprietary information.

Endogenous

RHOA ARH12 ARHA RHO12

Rho A

Transforming protein RhoA ;
Rho cDNA clone 12 ;
h12 ;

This gene encodes a member of the Rho family of small GTPases , which cycle between inactive GDP-bound and active GTP-bound states and function as molecular switches in signal transduction cascades. Rho proteins promote reorganization of the actin cytoskeleton and regulate cell shape , attachment , and motility. Overexpression of this gene is associated with tumor cell proliferation and metastasis. Multiple alternatively spliced variants have been identified. [provided by RefSeq , Sep 2015] ,

cofactor:Magnesium. ,Domain:The basic-rich region is essential for yopT recognition and cleavage. ,Function:Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Serves as a target for the yopT cysteine peptidase from Yersinia pestis , vector of the plague , and Yersinia pseudotuberculosis , which causes gastrointestinal disorders. May be an activator of PLCE1. Activated by ARHGEF2 , which promotes the exchange of GDP for GTP. ,PTM:Cleaved by yopT protease when the cell is infected by some Yersinia pathogens. This removes the lipid attachment , and leads to its displacement from plasma membrane and to subsequent cytoskeleton cleavage. ,PTM:Substrate for botulinum ADP-ribosyltransferase. ,similarity:Belongs to the small GTPase superfamily. Rho family. ,subunit:Interacts with RGNEF (By similarity) . Binds PRKCL1 , ROCK1 and ROCK2. Interacts with ARHGEF2 , ARHGEF3 , NET1 and RTKN. Interacts with PLCE1 and AKAP13. Interacts with human respiratory syncytial virus (HRSV) protein F; this interaction facilitates virus-induced syncytium formation. ,

Cell membrane; Lipid-anchor; Cytoplasmic side. Cytoplasm , cytoskeleton. Cleavage furrow. Cytoplasm , cell cortex . Midbody. Cell projection , lamellipodium . Cell projection , dendrite . Nucleus . Localized to cell-cell contacts in calcium-treated keratinocytes (By similarity) . Translocates to the equatorial region before furrow formation in a ECT2-dependent manner. Localizes to the equatorial cell cortex (at the site of the presumptive furrow) in early anaphase in an activated form and in a myosin- and actin-independent manner. .

>>Ras signaling pathway ;
>>Rap1 signaling pathway ;
>>cGMP-PKG signaling pathway ;
>>cAMP signaling pathway ;
>>Chemokine signaling pathway ;
>>Sphingolipid signaling pathway ;
>>Phospholipase D signaling pathway ;
>>Endocytosis ;
>>mTOR signaling pathway ;
>>Vascular smooth muscle contraction ;
>>Wnt signaling pathway ;
>>TGF-beta signaling pathway ;
>>Axon guidance ;
>>Focal adhesion ;
>>Adherens junction ;
>>Tight junction ;
>>Platelet activation ;
>>NOD-like receptor signaling pathway ;
>>C-type lectin receptor signaling pathway ;
>>T cell receptor signaling pathway ;
>>Leukocyte transendothelial migration ;
>>Neurotrophin signaling pathway ;
>>Regulation of actin cytoskeleton ;
>>Oxytocin signaling pathway ;
>>Parathyroid hormone synthesis , secretion and action ;
>>Pancreatic secretion ;
>>Bacterial invasion of epithelial cells ;
>>Pathogenic Escherichia coli infection ;
>>Shigellosis ;
>>Salmonella infection ;
>>Pertussis ;
>>Yersinia infection ;
>>Tuberculosis ;
>>Human cytomegalovirus infection ;
>>Pathways in cancer ;
>>Viral carcinogenesis ;
>>Proteoglycans in cancer ;
>>MicroRNAs in cancer ;
>>Colorectal cancer ;
>>Lipid and atherosclerosis ;
>>Fluid shear stress and atherosclerosis