SRP72 (PT0811R) PT™ Rabbit mAb
-YM8996
主要信息
Target
SRP72
Host Species
Rabbit
Reactivity
Human
Applications
WB, IHC, IF, ICC, FC
MW
74kD (Observed)
Conjugate/Modification
Unmodified
货号: YM8996
规格
价格
货期
数量
200μL
￥3,580.00
一周
0
100μL
￥1,960.00
一周
0
40μL
￥960.00
一周
0
加入购物车
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详细信息
推荐稀释比
WB 1:1000-5000; IHC 1:100-300; ICC/IF 1:100-300; FC 1:100-300
组成
PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
特异性
Endogenous
纯化工艺
Recombinant Antibody expressed in animal component-free (ACF) media, purified via Protein A affinity chromatography.
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
实测条带
74kD
修饰
Unmodified
克隆性
Monoclonal
克隆号
PT0811R
同种型
IgG,Kappa
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抗原&靶点信息
特异性:
Endogenous
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基因名称:
SRP72
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蛋白名称:
Signal recognition particle subunit SRP72;SRP72;Signal recognition particle 72 kDa protein;
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别名:
SRP72 ;
Signal recognition particle subunit SRP72 ;
SRP72 ;
Signal recognition particle 72 kDa protein ;
Signal recognition particle subunit SRP72 ;
SRP72 ;
Signal recognition particle 72 kDa protein ;
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背景:
This gene encodes the 72 kDa subunit of the signal recognition particle (SRP), a ribonucleoprotein complex that mediates the targeting of secretory proteins to the endoplasmic reticulum (ER). The SRP complex consists of a 7S RNA and 6 protein subunits: SRP9, SRP14, SRP19, SRP54, SRP68, and SRP72, that are bound to the 7S RNA as monomers or heterodimers. SRP has at least 3 distinct functions that can be associated with the protein subunits: signal recognition, translational arrest, and ER membrane targeting by interaction with the docking protein. Mutations in this gene are associated with familial bone marrow failure. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2012]
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功能:
Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER) (PubMed:34020957). The SRP complex interacts with the signal sequence in nascent secretory and membrane proteins and directs them to the membrane of the ER (PubMed:34020957). The SRP complex targets the ribosome-nascent chain complex to the SRP receptor (SR), which is anchored in the ER, where SR compaction and GTPase rearrangement drive cotranslational protein translocation into the ER (PubMed:34020957). Binds the signal recognition particle RNA (7SL RNA) in presence of SRP68 (PubMed:21073748, PubMed:27899666). Can bind 7SL RNA with low affinity (PubMed:21073748, PubMed:27899666). The SRP complex possibly participates in the elongation arrest function (By similarity). {ECO:0000250|UniProtKB:P38688, ECO:0000269|PubMed:21073748, ECO:0000269|PubMed:27899666, ECO:0000269|PubMed:34020957}.
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细胞定位:
Cytoplasm. Endoplasmic reticulum.
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货号: YM8996
规格
价格
货期
数量
200μL
￥3,580.00
一周
0
100μL
￥1,960.00
一周
0
40μL
￥960.00
一周
0
加入购物车
已收藏
收藏
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