The specific immunogen used to produce this antibody is proprietary information.

Endogenous

BCL2L2

Bcl-2-like protein 2

BCL2L2 ;
BCLW ;
KIAA0271 ;
Bcl-2-like protein 2 ;
Bcl2-L-2 ;
Apoptosis regulator Bcl-W

This gene encodes a member of the BCL-2 protein family. The proteins of this family form hetero- or homodimers and act as anti- and pro-apoptotic regulators. Expression of this gene in cells has been shown to contribute to reduced cell apoptosis under cytotoxic conditions. Studies of the related gene in mice indicated a role in the survival of NGF- and BDNF-dependent neurons. Mutation and knockout studies of the mouse gene demonstrated an essential role in adult spermatogenesis. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the neighboring downstream PABPN1 (poly (A) binding protein , nuclear 1) gene. [provided by RefSeq , Dec 2010] ,

Domain:The BH1 and BH2 motifs form a hydrophobic groove which acts as a docking site for the BH3 domain of some pro-apoptotic proteins. The C-terminal residues of BCL2L2 fold into the BH3-binding cleft and modulate pro-survival activity by regulating ligand access. When BH3 domain-containing proteins bind , they displace the C-terminus , allowing its insertion into the membrane and neutralizing the pro-survival activity of BCL2L2. ,Domain:The BH4 motif seems to be involved in the anti-apoptotic function. ,Function:Promotes cell survival. Blocks dexamethasone-induced apoptosis. Mediates survival of postmitotic Sertoli cells by suppressing death-promoting activity of BAX. ,similarity:Belongs to the Bcl-2 family. ,subcellular location:Loosely associated with the mitochondrial membrane in healthy cells. During apoptosis , tightly bound to the membrane. ,tissue specificity:Expressed (at protein level) in a wide range of tissues with highest levels in brain , spinal cord , testis , pancreas , heart , spleen and mammary glands. Moderate levels found in thymus , ovary and small intestine. Not detected in salivary gland , muscle or liver. Also expressed in cell lines of myeloid , fibroblast and epithelial origin. Not detected in most lymphoid cell lines. ,

Mitochondrion membrane ; Peripheral membrane protein . Loosely associated with the mitochondrial membrane in healthy cells. During apoptosis , tightly bound to the membrane.

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