MAGD1 Rabbit pAb
-YN1608
主要信息
Target
MAGD1
Host Species
Rabbit
Reactivity
Human, Mouse, Rat
Applications
WB, ELISA
MW
85kD (Observed)
Conjugate/Modification
Unmodified
货号: YN1608
规格
价格
货期
数量
200μL
￥3,780.00
现货
0
100μL
￥2,300.00
现货
0
40μL
￥960.00
现货
0
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详细信息
推荐稀释比
WB 1:500-2000; ELISA 1:5000-20000
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
特异性
MAGD1 Polyclonal Antibody detects endogenous levels of protein.
纯化工艺
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存
-15°C to -25°C/1 year (Do not lower than -25°C)
浓度
1 mg/ml
实测条带
85kD
修饰
Unmodified
克隆性
Polyclonal
同种型
IgG
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抗原&靶点信息
免疫原:
Synthesized peptide derived from human protein . at AA range: 200-280
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特异性:
MAGD1 Polyclonal Antibody detects endogenous levels of protein.
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基因名称:
MAGED1 NRAGE PP2250 PRO2292
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蛋白名称:
Melanoma-associated antigen D1 (MAGE tumor antigen CCF) (MAGE-D1 antigen) (Neurotrophin receptor-interacting MAGE homolog)
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背景:
This gene is a member of the melanoma antigen gene (MAGE) family. Most of the genes of this family encode tumor specific antigens that are not expressed in normal adult tissues except testis. Although the protein encoded by this gene shares strong homology with members of the MAGE family , it is expressed in almost all normal adult tissues. This gene has been demonstrated to be involved in the p75 neurotrophin receptor mediated programmed cell death pathway. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq , Jul 2008] ,
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功能:
Function:Involved in the apoptotic response after nerve growth factor (NGF) binding in neuronal cells. Binds p75NTR and antagonizes its association with TrkA , inhibits cell cycle progression , and facilitates p75NTR-mediated apoptosis. May act as a regulator of the function of DLX family members. May regulate p53 transcriptional activity and inhibit cell proliferation. Enhances p53 phosphorylation and accumulation. ,similarity:Contains 1 MAGE domain. ,subcellular location:Expression shifts from the cytoplasm to the plasma membrane upon stimulation with NGF. ,subunit:Interacts with DLX5 , DLX7 and MSX2 and forms homomultimers. Interacts with UNC5A (By similarity) . Interacts with the p75 neurotrophin receptor. ,tissue specificity:Expressed in bone marrow stromal cells from both multiple myeloma patients and healthy donors. Seems to be ubiquitously expressed. ,
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细胞定位:
Cytoplasm . Cell membrane ; Peripheral membrane protein . Nucleus . Expression shifts from the cytoplasm to the plasma membrane upon stimulation with NGF. .
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研究领域:
>>Neurotrophin signaling pathway
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文献引用（{{totalcount}}）
货号: YN1608
规格
价格
货期
数量
200μL
￥3,780.00
现货
0
100μL
￥2,300.00
现货
0
40μL
￥960.00
现货
0
加入购物车
已收藏
收藏
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