CDT1 Rabbit pAb
-YN0650
主要信息
Target
CDT1
Host Species
Rabbit
Reactivity
Human, Mouse
Applications
WB, ELISA
MW
60kD (Observed)
Conjugate/Modification
Unmodified
货号: YN0650
规格
价格
货期
数量
200μL
￥3,780.00
现货
0
100μL
￥2,300.00
现货
0
40μL
￥960.00
现货
0
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详细信息
推荐稀释比
WB 1:500-2000; ELISA 1:5000-20000
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
特异性
CDT1 Polyclonal Antibody detects endogenous levels of protein.
纯化工艺
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
浓度
1 mg/ml
实测条带
60kD
修饰
Unmodified
克隆性
Polyclonal
同种型
IgG
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抗原&靶点信息
免疫原:
Synthesized peptide derived from part region of human protein. AA range:141-191
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特异性:
CDT1 Polyclonal Antibody detects endogenous levels of protein.
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基因名称:
CDT1
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蛋白名称:
DNA replication factor Cdt1 (Double parked homolog) (DUP)
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背景:
The protein encoded by this gene is involved in the formation of the pre-replication complex that is necessary for DNA replication. The encoded protein can bind geminin, which prevents replication and may function to prevent this protein from initiating replication at inappropriate origins. Phosphorylation of this protein by cyclin A-dependent kinases results in degradation of the protein. [provided by RefSeq, Mar 2011],
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功能:
developmental stage:Present during G1 and early S phase of the cell cycle. Degraded during the late S, G2, and M phases.,Function:Cooperates with CDC6 to promote the loading of the mini-chromosome maintenance complex onto chromatin to form the pre-replication complex necessary to initiate DNA replication. Binds DNA in a sequence-, strand-, and conformation-independent manner. Potential oncogene.,PTM:Phosphorylated by cyclin A-dependent kinases which results in the binding of CDT1 to the F-box protein SKP2 and subsequent degradation. Binding to GMNN is not affected by phosphorylation.,PTM:Ubiquitinated, leading to its subsequent degradation. The interaction with GMNN protects it against ubiquitination.,similarity:Belongs to the Cdt1 family.,subunit:Interaction with GMNN inhibits both binding of the MCM complex to origins of replication and DNA-binding activity.,
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细胞定位:
Nucleus . Chromosome, centromere, kinetochore . Transiently localizes to kinetochores during prometaphase and metaphase. .
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文献引用（{{totalcount}}）
货号: YN0650
规格
价格
货期
数量
200μL
￥3,780.00
现货
0
100μL
￥2,300.00
现货
0
40μL
￥960.00
现货
0
加入购物车
已收藏
收藏
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