Synthesized peptide derived from human protein . at AA range: 1170-1250

KAT6B Polyclonal Antibody detects endogenous levels of protein.

KAT6B KIAA0383 MORF MOZ2 MYST4

Histone acetyltransferase KAT6B (Histone acetyltransferase MOZ2) (MOZ, YBF2/SAS3, SAS2 and TIP60 protein 4) (MYST-4) (Monocytic leukemia zinc finger protein-related factor)

The protein encoded by this gene is a histone acetyltransferase and component of the MOZ/MORF protein complex. In addition to its acetyltransferase activity , the encoded protein has transcriptional activation activity in its N-terminal end and transcriptional repression activity in its C-terminal end. This protein is necessary for RUNX2-dependent transcriptional activation and could be involved in brain development. Mutations have been found in patients with genitopatellar syndrome. A translocation of this gene and the CREBBP gene results in acute myeloid leukemias. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq , Mar 2012] ,

Catalytic activity:Acetyl-CoA + histone = CoA + acetylhistone. ,Disease:A chromosomal aberration involving MYST4 may be a cause acute myeloid leukemias. Translocation t (10;16) (q22;p13) with CREBBP. ,Domain:The N-terminus is involved in transcriptional activation while the C-terminus is involved in transcriptional repression. ,Function:Histone acetyltransferase which may be involved in both positive and negative regulation of transcription. Required for RUNX2-dependent transcriptional activation. May be involved in cerebral cortex development. Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity. ,PTM:Autoacetylated. ,sequence Caution:Contaminating sequence. Potential poly-A sequence. ,similarity:Belongs to the MYST (SAS/MOZ) family. ,similarity:Contains 1 C2HC-type zinc finger. ,similarity:Contains 2 PHD-type zinc fingers. ,subunit:Component of the MOZ/MORF composed at least of ING5 , MYST3/MOZ , MYST4/MORF and one of BRPF1 , BRD1/BRPF2 and BRPF3. Interacts with RUNX1 and RUNX2. ,tissue specificity:Ubiquitously expressed , with high levels in heart , pancreas , testis and ovary. ,

Nucleus .