AA range:25-95

Endogenous

ALB

ALB (Albumin)

ALB ;
GIG20 ;
GIG42 ;
Serum albumin

This gene encodes the most abundant protein in human blood. This protein functions in the regulation of blood plasma colloid osmotic pressure and acts as a carrier protein for a wide range of endogenous molecules including hormones , fatty acids , and metabolites , as well as exogenous drugs. Additionally , this protein exhibits an esterase-like activity with broad substrate specificity. The encoded preproprotein is proteolytically processed to generate the mature protein. A peptide derived from this protein , EPI-X4 , is an endogenous inhibitor of the CXCR4 chemokine receptor. [provided by RefSeq , Jul 2016] ,

Caution:A peptide arising from positions 166 to 174 was originally (PubMed:3087352 and PubMed:2437111) termed neurotensin-related peptide (NRP) or kinetensin and was thought to regulates fat digestion , lipid absorption , and blood flow. ,disease:A variant structure of albumin could lead to increased binding of zinc resulting in an asymptomatic augmentation of zinc concentration in the blood [MIM:194470]. ,disease:Defects in ALB are a cause of familial dysalbuminemic hyperthyroxinemia (FDH) [MIM:103600]. FDH is a form of euthyroid hyperthyroxinemia that is due to increased affinity of ALB for T (4) . It is the most common cause of inherited euthyroid hyperthyroxinemia in Caucasian population. ,Function:Serum albumin , the main protein of plasma , has a good binding capacity for water , Ca (2+) , Na (+) , K (+) , fatty acids , hormones , bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. ,miscellaneous:Acetylated on Lys-223 by acetylsalicylic acid. ,online information:Serum albumin entry ,polymorphism:The sequence shown is that of variant albumin A. ,PTM:Glycated in diabetic patients. ,PTM:Kenitra variant is partially O-glycosylated at Thr-620. It has two new disulfide bonds Cys-600 to Cys-602 and Cys-601 to Cys-606. ,similarity:Belongs to the ALB/AFP/VDB family. ,similarity:Contains 3 albumin domains. ,tissue specificity:Plasma. ,

Secreted

>>Thyroid hormone synthesis