The specific immunogen used to produce this antibody is proprietary information.

Endogenous

B3GAT1 GLCATP

Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1 (Beta-1,3-glucuronyltransferase 1) (Glucuronosyltransferase P) (GlcAT-P) (UDP-GlcUA:glycoprotein beta-1,3-glucuronyltransferase) (GlcUAT-P)

B3GAT1 ;
GLCATP ;
Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1 ;
Beta-1 ;
3-glucuronyltransferase 1 ;
Glucuronosyltransferase P ;
GlcAT-P ;
UDP-GlcUA:glycoprotein beta-1 ;
3-glucuronyltransferase ;
GlcUAT-P ;
CD57 nanobody ;

The protein encoded byThis gene is a member of the glucuronyltransferase gene family. These enzymes exhibit strict acceptor specificity , recognizing nonreducing terminal sugars and their anomeric linkages.This gene product functions as the key enzyme in a glucuronyl transfer reaction during the biosynthesis of the carbohydrate epitope HNK-1 (human natural killer-1 , also known as CD57 and LEU7) . Alternate transcriptional splice variants have been characterized. [provided by RefSeq , Jul 2008]

Catalytic activity:UDP-glucuronate + 3-beta-D-galactosyl-4-beta-D-galactosyl-O-beta-D-xylosylprotein = UDP + 3-beta-D-glucuronosyl-3-beta-D-galactosyl-4-beta-D-galactosyl-O-beta-D-xylosylprotein. ,cofactor:Manganese. ,Involved in the biosynthesis of L2/HNK-1 carbohydrate epitope on glycoproteins. Can also play a role in glycosaminoglycan biosynthesis. Substrates include asialo-orosomucoid (ASOR) , asialo-fetuin , and asialo-neural cell adhesion molecule. Requires sphingomyelin for activity: stearoyl-sphingomyelin was the most effective , followed by palmitoyl-sphingomyelin and lignoceroyl-sphingomyelin. Activity was demonstrated only for sphingomyelin with a saturated fatty acid and not for that with an unsaturated fatty acid , regardless of the length of the acyl group. ,online information:GlycoGene database ,pathway:Protein modification; protein glycosylation. ,similarity:Belongs to the glycosyltransferase 43 family. ,subunit:Homodimer . ,tissue specificity:Mainly expressed in the brain. ,

[Isoform 1]: Golgi apparatus membrane ; Single-pass type II membrane protein . Secreted .; [Isoform 2]: Golgi apparatus membrane ; Single-pass type II membrane protein . Endoplasmic reticulum membrane . Secreted .